Evidence and Therapeutic Perspectives in the Relationship between the Oral Microbiome and Alzheimer’s Disease: A Systematic Review

This review aims to clarify the nature of the link between Alzheimer’s disease and the oral microbiome on an epidemiological and pathophysiological level, as well as to highlight new therapeutic perspectives that contribute to the management of this disease. We performed a systematic review, followi...

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Autores principales:	Yoann Maitre, Rachid Mahalli, Pierre Micheneau, Alexis Delpierre, Gilles Amador, Frédéric Denis
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Alzheimer’s disease oral microbiota oral microbiome mental disorders Medicine R
Acceso en línea:	https://doaj.org/article/c37eceb150014490892802bd378ffd8f
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spelling	oai:doaj.org-article:c37eceb150014490892802bd378ffd8f2021-11-11T16:18:40ZEvidence and Therapeutic Perspectives in the Relationship between the Oral Microbiome and Alzheimer’s Disease: A Systematic Review10.3390/ijerph1821111571660-46011661-7827https://doaj.org/article/c37eceb150014490892802bd378ffd8f2021-10-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11157https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601This review aims to clarify the nature of the link between Alzheimer’s disease and the oral microbiome on an epidemiological and pathophysiological level, as well as to highlight new therapeutic perspectives that contribute to the management of this disease. We performed a systematic review, following the Preferred Reporting Items for Systematic Reviews checklist, from January 2000 to July 2021. The terms “plaque,” “saliva,” and “mouth” were associated with the search term “oral diseases” and used in combination with the Boolean operator “AND”/“OR”. We included experimental or clinical studies and excluded conferences, abstracts, reviews, and editorials. A total of 27 articles were selected. Evidence for the impact of the oral microbiome on the pathophysiological and immunoinflammatory mechanisms of Alzheimer’s disease is accumulating. The impact of the oral microbiome on the development of AD opens the door to complementary therapies such as phototherapy and/or the use of prebiotic compounds and probiotic strains for global or targeted modulation of the oral microbiome in order to have a favourable influence on the evolution of this pathology in the future.Yoann MaitreRachid MahalliPierre MicheneauAlexis DelpierreGilles AmadorFrédéric DenisMDPI AGarticleAlzheimer’s diseaseoral microbiotaoral microbiomemental disordersMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11157, p 11157 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease oral microbiota oral microbiome mental disorders Medicine R
spellingShingle	Alzheimer’s disease oral microbiota oral microbiome mental disorders Medicine R Yoann Maitre Rachid Mahalli Pierre Micheneau Alexis Delpierre Gilles Amador Frédéric Denis Evidence and Therapeutic Perspectives in the Relationship between the Oral Microbiome and Alzheimer’s Disease: A Systematic Review
description	This review aims to clarify the nature of the link between Alzheimer’s disease and the oral microbiome on an epidemiological and pathophysiological level, as well as to highlight new therapeutic perspectives that contribute to the management of this disease. We performed a systematic review, following the Preferred Reporting Items for Systematic Reviews checklist, from January 2000 to July 2021. The terms “plaque,” “saliva,” and “mouth” were associated with the search term “oral diseases” and used in combination with the Boolean operator “AND”/“OR”. We included experimental or clinical studies and excluded conferences, abstracts, reviews, and editorials. A total of 27 articles were selected. Evidence for the impact of the oral microbiome on the pathophysiological and immunoinflammatory mechanisms of Alzheimer’s disease is accumulating. The impact of the oral microbiome on the development of AD opens the door to complementary therapies such as phototherapy and/or the use of prebiotic compounds and probiotic strains for global or targeted modulation of the oral microbiome in order to have a favourable influence on the evolution of this pathology in the future.
format	article
author	Yoann Maitre Rachid Mahalli Pierre Micheneau Alexis Delpierre Gilles Amador Frédéric Denis
author_facet	Yoann Maitre Rachid Mahalli Pierre Micheneau Alexis Delpierre Gilles Amador Frédéric Denis
author_sort	Yoann Maitre
title	Evidence and Therapeutic Perspectives in the Relationship between the Oral Microbiome and Alzheimer’s Disease: A Systematic Review
title_short	Evidence and Therapeutic Perspectives in the Relationship between the Oral Microbiome and Alzheimer’s Disease: A Systematic Review
title_full	Evidence and Therapeutic Perspectives in the Relationship between the Oral Microbiome and Alzheimer’s Disease: A Systematic Review
title_fullStr	Evidence and Therapeutic Perspectives in the Relationship between the Oral Microbiome and Alzheimer’s Disease: A Systematic Review
title_full_unstemmed	Evidence and Therapeutic Perspectives in the Relationship between the Oral Microbiome and Alzheimer’s Disease: A Systematic Review
title_sort	evidence and therapeutic perspectives in the relationship between the oral microbiome and alzheimer’s disease: a systematic review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c37eceb150014490892802bd378ffd8f
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Evidence and Therapeutic Perspectives in the Relationship between the Oral Microbiome and Alzheimer’s Disease: A Systematic Review

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