Drug resistance and its risk factors among extrapulmonary tuberculosis in Ethiopia: A systematic review and meta-analysis.

<h4>Background</h4>Drug-resistant tuberculosis and extrapulmonary tuberculosis are the world major public health issues. Although some primary studies have been reported on the burden of drug-resistant tuberculosis in extrapulmonary tuberculosis patients in Ethiopia, there is no systemat...

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Autores principales:	Getu Diriba, Habteyes Hailu Tola, Ayinalem Alemu, Bazezew Yenew, Dinka Fikadu Gamtesa, Abebaw Kebede
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c380d1b5973744cbba2d84924f106ecd
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spelling	oai:doaj.org-article:c380d1b5973744cbba2d84924f106ecd2021-12-02T20:17:08ZDrug resistance and its risk factors among extrapulmonary tuberculosis in Ethiopia: A systematic review and meta-analysis.1932-620310.1371/journal.pone.0258295https://doaj.org/article/c380d1b5973744cbba2d84924f106ecd2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258295https://doaj.org/toc/1932-6203<h4>Background</h4>Drug-resistant tuberculosis and extrapulmonary tuberculosis are the world major public health issues. Although some primary studies have been reported on the burden of drug-resistant tuberculosis in extrapulmonary tuberculosis patients in Ethiopia, there is no systematic review and meta-analysis that attempt to summarize the available literature. Thus, we aimed to estimates the prevalence of drug-resistance in extrapulmonary tuberculosis patients and summarize the risk factors associated with the occurrence of extrapulmonary tuberculosis in Ethiopia.<h4>Methods</h4>We conducted a systematic review of the published primary studies on extrapulmonary drug-resistant tuberculosis in Ethiopia.<h4>Results</h4>Eight observational studies were included in this review from different regions of Ethiopia. The overall pooled prevalence of rifampicin resistance was 6% (95% CI 0.03-0.10), while isoniazid resistance was 7% (95% CI 0.03-0.12). The pooled prevalence of multidrug-resistant tuberculosis was 4% (95% CI 0.01-0.07). Previous tuberculosis treatment history and male gender are frequently reported risk factors for developing drug-resistant tuberculosis in extrapulmonary tuberculosis patients.<h4>Conclusion</h4>The current review has identified a high proportion of resistance to rifampicin, isoniazid, and multidrug-resistant tuberculosis in patients with extrapulmonary tuberculosis in Ethiopia. Clinicians should request drug susceptibility testing for all patients with presumptive extrapulmonary tuberculosis to detect drug-resistance.Getu DiribaHabteyes Hailu TolaAyinalem AlemuBazezew YenewDinka Fikadu GamtesaAbebaw KebedePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258295 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Getu Diriba Habteyes Hailu Tola Ayinalem Alemu Bazezew Yenew Dinka Fikadu Gamtesa Abebaw Kebede Drug resistance and its risk factors among extrapulmonary tuberculosis in Ethiopia: A systematic review and meta-analysis.
description	<h4>Background</h4>Drug-resistant tuberculosis and extrapulmonary tuberculosis are the world major public health issues. Although some primary studies have been reported on the burden of drug-resistant tuberculosis in extrapulmonary tuberculosis patients in Ethiopia, there is no systematic review and meta-analysis that attempt to summarize the available literature. Thus, we aimed to estimates the prevalence of drug-resistance in extrapulmonary tuberculosis patients and summarize the risk factors associated with the occurrence of extrapulmonary tuberculosis in Ethiopia.<h4>Methods</h4>We conducted a systematic review of the published primary studies on extrapulmonary drug-resistant tuberculosis in Ethiopia.<h4>Results</h4>Eight observational studies were included in this review from different regions of Ethiopia. The overall pooled prevalence of rifampicin resistance was 6% (95% CI 0.03-0.10), while isoniazid resistance was 7% (95% CI 0.03-0.12). The pooled prevalence of multidrug-resistant tuberculosis was 4% (95% CI 0.01-0.07). Previous tuberculosis treatment history and male gender are frequently reported risk factors for developing drug-resistant tuberculosis in extrapulmonary tuberculosis patients.<h4>Conclusion</h4>The current review has identified a high proportion of resistance to rifampicin, isoniazid, and multidrug-resistant tuberculosis in patients with extrapulmonary tuberculosis in Ethiopia. Clinicians should request drug susceptibility testing for all patients with presumptive extrapulmonary tuberculosis to detect drug-resistance.
format	article
author	Getu Diriba Habteyes Hailu Tola Ayinalem Alemu Bazezew Yenew Dinka Fikadu Gamtesa Abebaw Kebede
author_facet	Getu Diriba Habteyes Hailu Tola Ayinalem Alemu Bazezew Yenew Dinka Fikadu Gamtesa Abebaw Kebede
author_sort	Getu Diriba
title	Drug resistance and its risk factors among extrapulmonary tuberculosis in Ethiopia: A systematic review and meta-analysis.
title_short	Drug resistance and its risk factors among extrapulmonary tuberculosis in Ethiopia: A systematic review and meta-analysis.
title_full	Drug resistance and its risk factors among extrapulmonary tuberculosis in Ethiopia: A systematic review and meta-analysis.
title_fullStr	Drug resistance and its risk factors among extrapulmonary tuberculosis in Ethiopia: A systematic review and meta-analysis.
title_full_unstemmed	Drug resistance and its risk factors among extrapulmonary tuberculosis in Ethiopia: A systematic review and meta-analysis.
title_sort	drug resistance and its risk factors among extrapulmonary tuberculosis in ethiopia: a systematic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c380d1b5973744cbba2d84924f106ecd
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Drug resistance and its risk factors among extrapulmonary tuberculosis in Ethiopia: A systematic review and meta-analysis.

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