Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits

The potential links between infections and neurodegenerative disorders are unclear. Here, Wu et al. present a mouse model of low-grade candidemia characterized by highly localized cerebritis, accumulation of amyloid precursor protein and beta peptides, and mild memory impairment that resolves with f...

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Autores principales:	Yifan Wu, Shuqi Du, Jennifer L. Johnson, Hui-Ying Tung, Cameron T. Landers, Yuwei Liu, Brittany G. Seman, Robert T. Wheeler, Mauro Costa-Mattioli, Farrah Kheradmand, Hui Zheng, David B. Corry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c3813590dc9a4ea3abc0fbb7fbabc074
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spelling	oai:doaj.org-article:c3813590dc9a4ea3abc0fbb7fbabc0742021-12-02T17:01:37ZMicroglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits10.1038/s41467-018-07991-42041-1723https://doaj.org/article/c3813590dc9a4ea3abc0fbb7fbabc0742019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07991-4https://doaj.org/toc/2041-1723The potential links between infections and neurodegenerative disorders are unclear. Here, Wu et al. present a mouse model of low-grade candidemia characterized by highly localized cerebritis, accumulation of amyloid precursor protein and beta peptides, and mild memory impairment that resolves with fungal clearance.Yifan WuShuqi DuJennifer L. JohnsonHui-Ying TungCameron T. LandersYuwei LiuBrittany G. SemanRobert T. WheelerMauro Costa-MattioliFarrah KheradmandHui ZhengDavid B. CorryNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yifan Wu Shuqi Du Jennifer L. Johnson Hui-Ying Tung Cameron T. Landers Yuwei Liu Brittany G. Seman Robert T. Wheeler Mauro Costa-Mattioli Farrah Kheradmand Hui Zheng David B. Corry Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits
description	The potential links between infections and neurodegenerative disorders are unclear. Here, Wu et al. present a mouse model of low-grade candidemia characterized by highly localized cerebritis, accumulation of amyloid precursor protein and beta peptides, and mild memory impairment that resolves with fungal clearance.
format	article
author	Yifan Wu Shuqi Du Jennifer L. Johnson Hui-Ying Tung Cameron T. Landers Yuwei Liu Brittany G. Seman Robert T. Wheeler Mauro Costa-Mattioli Farrah Kheradmand Hui Zheng David B. Corry
author_facet	Yifan Wu Shuqi Du Jennifer L. Johnson Hui-Ying Tung Cameron T. Landers Yuwei Liu Brittany G. Seman Robert T. Wheeler Mauro Costa-Mattioli Farrah Kheradmand Hui Zheng David B. Corry
author_sort	Yifan Wu
title	Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits
title_short	Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits
title_full	Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits
title_fullStr	Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits
title_full_unstemmed	Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits
title_sort	microglia and amyloid precursor protein coordinate control of transient candida cerebritis with memory deficits
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c3813590dc9a4ea3abc0fbb7fbabc074
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Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits

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