α-Synuclein promotes IAPP fibril formation in vitro and β-cell amyloid formation in vivo in mice

α-Synuclein promotes IAPP fibril formation in vitro and β-cell amyloid formation in vivo in mice

Abstract Type 2 diabetes (T2D), alike Parkinson’s disease (PD), belongs to the group of protein misfolding diseases (PMDs), which share aggregation of misfolded proteins as a hallmark. Although the major aggregating peptide in β-cells of T2D patients is Islet Amyloid Polypeptide (IAPP), alpha-synucl...

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Autores principales: Marija Mucibabic, Pär Steneberg, Emmelie Lidh, Jurate Straseviciene, Agnieszka Ziolkowska, Ulf Dahl, Emma Lindahl, Helena Edlund
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Medicine
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Science
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Acceso en línea:https://doaj.org/article/c38137531696423c9b543012d50e5640
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