Stroke risk associated with NSAIDs uses in women with dysmenorrhea: A population-based cohort study

<h4>Objective</h4> Dysmenorrhea is among the most common type of gynecological problem, affecting young women across the globe. This study assessed the comparative risk of stroke associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and non-NSAIDs in women with dysmeno...

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Autores principales:	Ya-Wen Lin, Jong-Yi Wang, Ming-Hung Lin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c3821e33d37b487ea602da33c9d33b62
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spelling	oai:doaj.org-article:c3821e33d37b487ea602da33c9d33b622021-11-25T06:11:04ZStroke risk associated with NSAIDs uses in women with dysmenorrhea: A population-based cohort study1932-6203https://doaj.org/article/c3821e33d37b487ea602da33c9d33b622021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589167/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4> Dysmenorrhea is among the most common type of gynecological problem, affecting young women across the globe. This study assessed the comparative risk of stroke associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and non-NSAIDs in women with dysmenorrhea while taking into account the following factors such as age, history of pregnancy, NSAIDs uses and its duration of use, and selected comorbidities. <h4>Methodology</h4> We used a quantitative research approach based on a comparative case-control study design. The study data was selected from the Longitudinal Health Insurance Database (LHID) 2000, of the Taiwan National Health Research Institutes. Among the estimated 23.4 million insured Taiwanese, who were covered by the Taiwan health insurance system, in the 2000 registry of beneficiaries, one million individuals were randomly selected from the database. A total of 24,955 females suffering from dysmenorrhea were selected for the study. Out of those 3238 (13%) participated in the study group and 21,717 (87%) were randomly distributed into the controls group. Women in the age range, 15–49 years, who did not have any history of stroke, hysterectomy, and/or ovariectomy, were included in the study. A comparative proportional distribution analysis was used for data analysis. <h4>Results</h4> Age and use of NSAIDs and its duration of usage were factors associated with an increased incidence of stroke. The stroke incidence rate was 12.77 per 10,000 person-years, and 1.83-fold higher in NSAIDs use cohort than in comparisons with adjusted hazard ratio (aHR) of 1.47 (95% CI = 0.93–2.32). Among women with dysmenorrhea use of NSAIDs, the stroke incidence increased to 2.29-fold (aHR 95% CI = 1.36–3.84) in those use for ≧24 days per month and to 0.51-fold (aHR 95% CI = 0.13–2.10) in those use for 6–12 days per month. <h4>Conclusions</h4> Women with dysmenorrhea who use NSAIDs have a higher risk of stroke. Especially young women, the risk of stroke is further increased, and the longer the medication, the higher the risk of stroke. Every woman with symptoms of dysmenorrhea deserves specialized outpatient treatment and care.Ya-Wen LinJong-Yi WangMing-Hung LinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ya-Wen Lin Jong-Yi Wang Ming-Hung Lin Stroke risk associated with NSAIDs uses in women with dysmenorrhea: A population-based cohort study
description	<h4>Objective</h4> Dysmenorrhea is among the most common type of gynecological problem, affecting young women across the globe. This study assessed the comparative risk of stroke associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and non-NSAIDs in women with dysmenorrhea while taking into account the following factors such as age, history of pregnancy, NSAIDs uses and its duration of use, and selected comorbidities. <h4>Methodology</h4> We used a quantitative research approach based on a comparative case-control study design. The study data was selected from the Longitudinal Health Insurance Database (LHID) 2000, of the Taiwan National Health Research Institutes. Among the estimated 23.4 million insured Taiwanese, who were covered by the Taiwan health insurance system, in the 2000 registry of beneficiaries, one million individuals were randomly selected from the database. A total of 24,955 females suffering from dysmenorrhea were selected for the study. Out of those 3238 (13%) participated in the study group and 21,717 (87%) were randomly distributed into the controls group. Women in the age range, 15–49 years, who did not have any history of stroke, hysterectomy, and/or ovariectomy, were included in the study. A comparative proportional distribution analysis was used for data analysis. <h4>Results</h4> Age and use of NSAIDs and its duration of usage were factors associated with an increased incidence of stroke. The stroke incidence rate was 12.77 per 10,000 person-years, and 1.83-fold higher in NSAIDs use cohort than in comparisons with adjusted hazard ratio (aHR) of 1.47 (95% CI = 0.93–2.32). Among women with dysmenorrhea use of NSAIDs, the stroke incidence increased to 2.29-fold (aHR 95% CI = 1.36–3.84) in those use for ≧24 days per month and to 0.51-fold (aHR 95% CI = 0.13–2.10) in those use for 6–12 days per month. <h4>Conclusions</h4> Women with dysmenorrhea who use NSAIDs have a higher risk of stroke. Especially young women, the risk of stroke is further increased, and the longer the medication, the higher the risk of stroke. Every woman with symptoms of dysmenorrhea deserves specialized outpatient treatment and care.
format	article
author	Ya-Wen Lin Jong-Yi Wang Ming-Hung Lin
author_facet	Ya-Wen Lin Jong-Yi Wang Ming-Hung Lin
author_sort	Ya-Wen Lin
title	Stroke risk associated with NSAIDs uses in women with dysmenorrhea: A population-based cohort study
title_short	Stroke risk associated with NSAIDs uses in women with dysmenorrhea: A population-based cohort study
title_full	Stroke risk associated with NSAIDs uses in women with dysmenorrhea: A population-based cohort study
title_fullStr	Stroke risk associated with NSAIDs uses in women with dysmenorrhea: A population-based cohort study
title_full_unstemmed	Stroke risk associated with NSAIDs uses in women with dysmenorrhea: A population-based cohort study
title_sort	stroke risk associated with nsaids uses in women with dysmenorrhea: a population-based cohort study
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c3821e33d37b487ea602da33c9d33b62
work_keys_str_mv	AT yawenlin strokeriskassociatedwithnsaidsusesinwomenwithdysmenorrheaapopulationbasedcohortstudy AT jongyiwang strokeriskassociatedwithnsaidsusesinwomenwithdysmenorrheaapopulationbasedcohortstudy AT minghunglin strokeriskassociatedwithnsaidsusesinwomenwithdysmenorrheaapopulationbasedcohortstudy
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Stroke risk associated with NSAIDs uses in women with dysmenorrhea: A population-based cohort study

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