Abnormal auditory forward masking pattern in the brainstem response of individuals with Asperger syndrome

Johan K&auml;llstrand1, Olle Olsson2, Sara Fristedt Nehlstedt1, Mia Ling Sk&ouml;ld1, S&ouml;ren Nielz&eacute;n21SensoDetect AB, Lund, Sweden; 2Department of Clinical Neuroscience, Section of Psychiatry, Lund University, Lund, SwedenAbstract: Abnormal auditory informa...

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Autores principales:	Johan K&auml;llstrand, Olle Olsson, Sara Fristedt Nehlstedt, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c38306a49f4f41e79e5a8e3662d53461
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spelling	oai:doaj.org-article:c38306a49f4f41e79e5a8e3662d534612021-12-02T05:18:19ZAbnormal auditory forward masking pattern in the brainstem response of individuals with Asperger syndrome1176-63281178-2021https://doaj.org/article/c38306a49f4f41e79e5a8e3662d534612010-05-01T00:00:00Zhttp://www.dovepress.com/abnormal-auditory-forward-masking-pattern-in-the-brainstem-response-of-a4529https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Johan K&auml;llstrand1, Olle Olsson2, Sara Fristedt Nehlstedt1, Mia Ling Sk&ouml;ld1, S&ouml;ren Nielz&eacute;n21SensoDetect AB, Lund, Sweden; 2Department of Clinical Neuroscience, Section of Psychiatry, Lund University, Lund, SwedenAbstract: Abnormal auditory information processing has been reported in individuals with autism spectrum disorders (ASD). In the present study auditory processing was investigated by recording auditory brainstem responses (ABRs) elicited by forward masking in adults diagnosed with Asperger syndrome (AS). Sixteen AS subjects were included in the forward masking experiment and compared to three control groups consisting of healthy individuals (n = 16), schizophrenic patients (n = 16) and attention deficit hyperactivity disorder patients (n = 16), respectively, of matching age and gender. The results showed that the AS subjects exhibited abnormally low activity in the early part of their ABRs that distinctly separated them from the three control groups. Specifically, wave III amplitudes were significantly lower in the AS group than for all the control groups in the forward masking condition (P &lt; 0.005), which was not the case in the baseline condition. Thus, electrophysiological measurements of ABRs to complex sound stimuli (eg, forward masking) may lead to a better understanding of the underlying neurophysiology of AS. Future studies may further point to specific ABR characteristics in AS individuals that separate them from individuals diagnosed with other neurodevelopmental diseases.Keywords: asperger syndrome, auditory brainstem response, forward masking, psychoacoustics Johan K&auml;llstrandOlle OlssonSara Fristedt Nehlstedtet alDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2010, Iss Issue 1, Pp 289-296 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Johan K&auml;llstrand Olle Olsson Sara Fristedt Nehlstedt et al Abnormal auditory forward masking pattern in the brainstem response of individuals with Asperger syndrome
description	Johan K&auml;llstrand1, Olle Olsson2, Sara Fristedt Nehlstedt1, Mia Ling Sk&ouml;ld1, S&ouml;ren Nielz&eacute;n21SensoDetect AB, Lund, Sweden; 2Department of Clinical Neuroscience, Section of Psychiatry, Lund University, Lund, SwedenAbstract: Abnormal auditory information processing has been reported in individuals with autism spectrum disorders (ASD). In the present study auditory processing was investigated by recording auditory brainstem responses (ABRs) elicited by forward masking in adults diagnosed with Asperger syndrome (AS). Sixteen AS subjects were included in the forward masking experiment and compared to three control groups consisting of healthy individuals (n = 16), schizophrenic patients (n = 16) and attention deficit hyperactivity disorder patients (n = 16), respectively, of matching age and gender. The results showed that the AS subjects exhibited abnormally low activity in the early part of their ABRs that distinctly separated them from the three control groups. Specifically, wave III amplitudes were significantly lower in the AS group than for all the control groups in the forward masking condition (P &lt; 0.005), which was not the case in the baseline condition. Thus, electrophysiological measurements of ABRs to complex sound stimuli (eg, forward masking) may lead to a better understanding of the underlying neurophysiology of AS. Future studies may further point to specific ABR characteristics in AS individuals that separate them from individuals diagnosed with other neurodevelopmental diseases.Keywords: asperger syndrome, auditory brainstem response, forward masking, psychoacoustics
format	article
author	Johan K&auml;llstrand Olle Olsson Sara Fristedt Nehlstedt et al
author_facet	Johan K&auml;llstrand Olle Olsson Sara Fristedt Nehlstedt et al
author_sort	Johan K&auml;llstrand
title	Abnormal auditory forward masking pattern in the brainstem response of individuals with Asperger syndrome
title_short	Abnormal auditory forward masking pattern in the brainstem response of individuals with Asperger syndrome
title_full	Abnormal auditory forward masking pattern in the brainstem response of individuals with Asperger syndrome
title_fullStr	Abnormal auditory forward masking pattern in the brainstem response of individuals with Asperger syndrome
title_full_unstemmed	Abnormal auditory forward masking pattern in the brainstem response of individuals with Asperger syndrome
title_sort	abnormal auditory forward masking pattern in the brainstem response of individuals with asperger syndrome
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/c38306a49f4f41e79e5a8e3662d53461
work_keys_str_mv	AT johankampaumlllstrand abnormalauditoryforwardmaskingpatterninthebrainstemresponseofindividualswithaspergersyndrome AT olleolsson abnormalauditoryforwardmaskingpatterninthebrainstemresponseofindividualswithaspergersyndrome AT sarafristedtnehlstedt abnormalauditoryforwardmaskingpatterninthebrainstemresponseofindividualswithaspergersyndrome AT etal abnormalauditoryforwardmaskingpatterninthebrainstemresponseofindividualswithaspergersyndrome
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Abnormal auditory forward masking pattern in the brainstem response of individuals with Asperger syndrome

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