A beta-lactam antibiotic dampens excitotoxic inflammatory CNS damage in a mouse model of multiple sclerosis.

A beta-lactam antibiotic dampens excitotoxic inflammatory CNS damage in a mouse model of multiple sclerosis.

In multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), impairment of glial "Excitatory Amino Acid Transporters" (EAATs) together with an excess glutamate-release by invading immune cells causes excitotoxic damage of the central nervous system (CNS)...

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Autores principales: Nico Melzer, Sven G Meuth, Delany Torres-Salazar, Stefan Bittner, Alla L Zozulya, Christian Weidenfeller, Alexandra Kotsiari, Martin Stangel, Christoph Fahlke, Heinz Wiendl
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2008
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/c383107def234f8f910ee1adc3e6c305
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