Reduced reward-related probability learning in schizophrenia patients

Alpaslan Yilmaz1,2, Fatma Simsek2, Ali Saffet Gonul2,31Department of Sport and Health, Physical Education and Sports College, Erciyes University, Kayseri, Turkey; 2Department of Psychiatry, SoCAT Lab, Ege University School of Medicine, Bornova, Izmir, Turkey; 3Department of Psychiatry and Behavioral...

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Autores principales:	Yılmaz A, Simsek F, Gonul AS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c386bb35f8a2492ca9bf903d08859151
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spelling	oai:doaj.org-article:c386bb35f8a2492ca9bf903d088591512021-12-02T07:25:51ZReduced reward-related probability learning in schizophrenia patients1176-63281178-2021https://doaj.org/article/c386bb35f8a2492ca9bf903d088591512012-01-01T00:00:00Zhttp://www.dovepress.com/reduced-reward-related-probability-learning-in-schizophrenia-patients-a9001https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Alpaslan Yilmaz1,2, Fatma Simsek2, Ali Saffet Gonul2,31Department of Sport and Health, Physical Education and Sports College, Erciyes University, Kayseri, Turkey; 2Department of Psychiatry, SoCAT Lab, Ege University School of Medicine, Bornova, Izmir, Turkey; 3Department of Psychiatry and Behavioral Sciences, Mercer University School of Medicine, Macon, GA, USAAbstract: Although it is known that individuals with schizophrenia demonstrate marked impairment in reinforcement learning, the details of this impairment are not known. The aim of this study was to test the hypothesis that reward-related probability learning is altered in schizophrenia patients. Twenty-five clinically stable schizophrenia patients and 25 age- and gender-matched controls participated in the study. A simple gambling paradigm was used in which five different cues were associated with different reward probabilities (50%, 67%, and 100%). Participants were asked to make their best guess about the reward probability of each cue. Compared with controls, patients had significant impairment in learning contingencies on the basis of reward-related feedback. The correlation analyses revealed that the impairment of patients partially correlated with the severity of negative symptoms as measured on the Positive and Negative Syndrome Scale but that it was not related to antipsychotic dose. In conclusion, the present study showed that the schizophrenia patients had impaired reward-based learning and that this was independent from their medication status.Keywords: reinforcement learning, reward, punishment, motivationYılmaz ASimsek FGonul ASDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2012, Iss default, Pp 27-34 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Yılmaz A Simsek F Gonul AS Reduced reward-related probability learning in schizophrenia patients
description	Alpaslan Yilmaz1,2, Fatma Simsek2, Ali Saffet Gonul2,31Department of Sport and Health, Physical Education and Sports College, Erciyes University, Kayseri, Turkey; 2Department of Psychiatry, SoCAT Lab, Ege University School of Medicine, Bornova, Izmir, Turkey; 3Department of Psychiatry and Behavioral Sciences, Mercer University School of Medicine, Macon, GA, USAAbstract: Although it is known that individuals with schizophrenia demonstrate marked impairment in reinforcement learning, the details of this impairment are not known. The aim of this study was to test the hypothesis that reward-related probability learning is altered in schizophrenia patients. Twenty-five clinically stable schizophrenia patients and 25 age- and gender-matched controls participated in the study. A simple gambling paradigm was used in which five different cues were associated with different reward probabilities (50%, 67%, and 100%). Participants were asked to make their best guess about the reward probability of each cue. Compared with controls, patients had significant impairment in learning contingencies on the basis of reward-related feedback. The correlation analyses revealed that the impairment of patients partially correlated with the severity of negative symptoms as measured on the Positive and Negative Syndrome Scale but that it was not related to antipsychotic dose. In conclusion, the present study showed that the schizophrenia patients had impaired reward-based learning and that this was independent from their medication status.Keywords: reinforcement learning, reward, punishment, motivation
format	article
author	Yılmaz A Simsek F Gonul AS
author_facet	Yılmaz A Simsek F Gonul AS
author_sort	Yılmaz A
title	Reduced reward-related probability learning in schizophrenia patients
title_short	Reduced reward-related probability learning in schizophrenia patients
title_full	Reduced reward-related probability learning in schizophrenia patients
title_fullStr	Reduced reward-related probability learning in schizophrenia patients
title_full_unstemmed	Reduced reward-related probability learning in schizophrenia patients
title_sort	reduced reward-related probability learning in schizophrenia patients
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/c386bb35f8a2492ca9bf903d08859151
work_keys_str_mv	AT yılmaza reducedrewardrelatedprobabilitylearninginschizophreniapatients AT simsekf reducedrewardrelatedprobabilitylearninginschizophreniapatients AT gonulas reducedrewardrelatedprobabilitylearninginschizophreniapatients
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Reduced reward-related probability learning in schizophrenia patients

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