The Pathological Mechanisms of Estrogen-Induced Cholestasis: Current Perspectives

Estrogens are steroid hormones with a wide range of biological activities. The excess of estrogens can lead to decreased bile flow, toxic bile acid (BA) accumulation, subsequently causing intrahepatic cholestasis. Estrogen-induced cholestasis (EIC) may have increased incidence during pregnancy, and...

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Autores principales:	Yue Zu, Jinyu Yang, Chengliang Zhang, Dong Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	estrogens bile acid homeostasis transporter membrane fluidity inflammation intrahepatic cholestasis Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c3887f202b184b8291dce312e1195b85
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spelling	oai:doaj.org-article:c3887f202b184b8291dce312e1195b852021-11-08T07:42:49ZThe Pathological Mechanisms of Estrogen-Induced Cholestasis: Current Perspectives1663-981210.3389/fphar.2021.761255https://doaj.org/article/c3887f202b184b8291dce312e1195b852021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.761255/fullhttps://doaj.org/toc/1663-9812Estrogens are steroid hormones with a wide range of biological activities. The excess of estrogens can lead to decreased bile flow, toxic bile acid (BA) accumulation, subsequently causing intrahepatic cholestasis. Estrogen-induced cholestasis (EIC) may have increased incidence during pregnancy, and within women taking oral contraception and postmenopausal hormone replacement therapy, and result in liver injury, preterm birth, meconium-stained amniotic fluid, and intrauterine fetal death in pregnant women. The main pathogenic mechanisms of EIC may include deregulation of BA synthetic or metabolic enzymes, and BA transporters. In addition, impaired cell membrane fluidity, inflammatory responses and change of hepatocyte tight junctions are also involved in the pathogenesis of EIC. In this article, we review the role of estrogens in intrahepatic cholestasis, and outlined the mechanisms of EIC, providing a greater understanding of this disease.Yue ZuJinyu YangChengliang ZhangDong LiuFrontiers Media S.A.articleestrogensbile acid homeostasistransportermembrane fluidityinflammationintrahepatic cholestasisTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	estrogens bile acid homeostasis transporter membrane fluidity inflammation intrahepatic cholestasis Therapeutics. Pharmacology RM1-950
spellingShingle	estrogens bile acid homeostasis transporter membrane fluidity inflammation intrahepatic cholestasis Therapeutics. Pharmacology RM1-950 Yue Zu Jinyu Yang Chengliang Zhang Dong Liu The Pathological Mechanisms of Estrogen-Induced Cholestasis: Current Perspectives
description	Estrogens are steroid hormones with a wide range of biological activities. The excess of estrogens can lead to decreased bile flow, toxic bile acid (BA) accumulation, subsequently causing intrahepatic cholestasis. Estrogen-induced cholestasis (EIC) may have increased incidence during pregnancy, and within women taking oral contraception and postmenopausal hormone replacement therapy, and result in liver injury, preterm birth, meconium-stained amniotic fluid, and intrauterine fetal death in pregnant women. The main pathogenic mechanisms of EIC may include deregulation of BA synthetic or metabolic enzymes, and BA transporters. In addition, impaired cell membrane fluidity, inflammatory responses and change of hepatocyte tight junctions are also involved in the pathogenesis of EIC. In this article, we review the role of estrogens in intrahepatic cholestasis, and outlined the mechanisms of EIC, providing a greater understanding of this disease.
format	article
author	Yue Zu Jinyu Yang Chengliang Zhang Dong Liu
author_facet	Yue Zu Jinyu Yang Chengliang Zhang Dong Liu
author_sort	Yue Zu
title	The Pathological Mechanisms of Estrogen-Induced Cholestasis: Current Perspectives
title_short	The Pathological Mechanisms of Estrogen-Induced Cholestasis: Current Perspectives
title_full	The Pathological Mechanisms of Estrogen-Induced Cholestasis: Current Perspectives
title_fullStr	The Pathological Mechanisms of Estrogen-Induced Cholestasis: Current Perspectives
title_full_unstemmed	The Pathological Mechanisms of Estrogen-Induced Cholestasis: Current Perspectives
title_sort	pathological mechanisms of estrogen-induced cholestasis: current perspectives
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c3887f202b184b8291dce312e1195b85
work_keys_str_mv	AT yuezu thepathologicalmechanismsofestrogeninducedcholestasiscurrentperspectives AT jinyuyang thepathologicalmechanismsofestrogeninducedcholestasiscurrentperspectives AT chengliangzhang thepathologicalmechanismsofestrogeninducedcholestasiscurrentperspectives AT dongliu thepathologicalmechanismsofestrogeninducedcholestasiscurrentperspectives AT yuezu pathologicalmechanismsofestrogeninducedcholestasiscurrentperspectives AT jinyuyang pathologicalmechanismsofestrogeninducedcholestasiscurrentperspectives AT chengliangzhang pathologicalmechanismsofestrogeninducedcholestasiscurrentperspectives AT dongliu pathologicalmechanismsofestrogeninducedcholestasiscurrentperspectives
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The Pathological Mechanisms of Estrogen-Induced Cholestasis: Current Perspectives

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