Measurement of serum ACE status may potentially improve the diagnosis of SARS-CoV-2 infection

The severity of SARS-CoV-2 infection is associated with underlying cardiovascular or pulmonary pathological conditions. The fatality rate of this typical pneumonia has superseded the two previous coronavirus epidemics combined. Thus far, comprehensive diagnosis of SARS-CoV-2 remains essential for ef...

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Autor principal:	Gcinokwakhe D Ngcobo
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	SARS-CoV-2 Angiotensin-converting enzyme (ACE) Angiotensin-converting enzyme-2 (ACE2) Angiotensin II Prognostic biomarker Pro-inflammatory cytokines Science Q
Acceso en línea:	https://doaj.org/article/c3888b6de08d47a4ac213e89a70d7c8f
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spelling	oai:doaj.org-article:c3888b6de08d47a4ac213e89a70d7c8f2021-11-24T04:32:50ZMeasurement of serum ACE status may potentially improve the diagnosis of SARS-CoV-2 infection2468-227610.1016/j.sciaf.2021.e01039https://doaj.org/article/c3888b6de08d47a4ac213e89a70d7c8f2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2468227621003409https://doaj.org/toc/2468-2276The severity of SARS-CoV-2 infection is associated with underlying cardiovascular or pulmonary pathological conditions. The fatality rate of this typical pneumonia has superseded the two previous coronavirus epidemics combined. Thus far, comprehensive diagnosis of SARS-CoV-2 remains essential for effective screening, detection, and disease monitoring. This allows employment of different life-saving interventions to lower the spread and mortality, whilst the development of labelled therapeutics is underway. In this perspective, the measurement of Angiotensin-converting enzyme (ACE) status is perceived as a potential prognostic biomarker for SARS-CoV-2 patients. This notion is based on the observation that SARS-CoV-2 infection via attachment to Angiotensin-converting enzyme-2 (ACE2) receptor, downregulates ACE2 expression. Thus leading to the inability to efficiently counter-regulate the damaging effects of its homolog; ACE. The perspective is further strengthened by the recommendations of therapeutics that attenuate the conversion of Angiotensin I to a vasoconstrictor; Angiotensin II as an effective treatment of SARS-CoV-2 infection. In addition, other off-labelled used drugs target the latter; restoration of multiple organ failure and or cytokine storm inhibition. Therefore, this suggests that ACE may be strongly implicated in the pathogenesis of SARS-CoV-2.Gcinokwakhe D NgcoboElsevierarticleSARS-CoV-2Angiotensin-converting enzyme (ACE)Angiotensin-converting enzyme-2 (ACE2)Angiotensin IIPrognostic biomarkerPro-inflammatory cytokinesScienceQENScientific African, Vol 14, Iss , Pp e01039- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 Angiotensin-converting enzyme (ACE) Angiotensin-converting enzyme-2 (ACE2) Angiotensin II Prognostic biomarker Pro-inflammatory cytokines Science Q
spellingShingle	SARS-CoV-2 Angiotensin-converting enzyme (ACE) Angiotensin-converting enzyme-2 (ACE2) Angiotensin II Prognostic biomarker Pro-inflammatory cytokines Science Q Gcinokwakhe D Ngcobo Measurement of serum ACE status may potentially improve the diagnosis of SARS-CoV-2 infection
description	The severity of SARS-CoV-2 infection is associated with underlying cardiovascular or pulmonary pathological conditions. The fatality rate of this typical pneumonia has superseded the two previous coronavirus epidemics combined. Thus far, comprehensive diagnosis of SARS-CoV-2 remains essential for effective screening, detection, and disease monitoring. This allows employment of different life-saving interventions to lower the spread and mortality, whilst the development of labelled therapeutics is underway. In this perspective, the measurement of Angiotensin-converting enzyme (ACE) status is perceived as a potential prognostic biomarker for SARS-CoV-2 patients. This notion is based on the observation that SARS-CoV-2 infection via attachment to Angiotensin-converting enzyme-2 (ACE2) receptor, downregulates ACE2 expression. Thus leading to the inability to efficiently counter-regulate the damaging effects of its homolog; ACE. The perspective is further strengthened by the recommendations of therapeutics that attenuate the conversion of Angiotensin I to a vasoconstrictor; Angiotensin II as an effective treatment of SARS-CoV-2 infection. In addition, other off-labelled used drugs target the latter; restoration of multiple organ failure and or cytokine storm inhibition. Therefore, this suggests that ACE may be strongly implicated in the pathogenesis of SARS-CoV-2.
format	article
author	Gcinokwakhe D Ngcobo
author_facet	Gcinokwakhe D Ngcobo
author_sort	Gcinokwakhe D Ngcobo
title	Measurement of serum ACE status may potentially improve the diagnosis of SARS-CoV-2 infection
title_short	Measurement of serum ACE status may potentially improve the diagnosis of SARS-CoV-2 infection
title_full	Measurement of serum ACE status may potentially improve the diagnosis of SARS-CoV-2 infection
title_fullStr	Measurement of serum ACE status may potentially improve the diagnosis of SARS-CoV-2 infection
title_full_unstemmed	Measurement of serum ACE status may potentially improve the diagnosis of SARS-CoV-2 infection
title_sort	measurement of serum ace status may potentially improve the diagnosis of sars-cov-2 infection
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c3888b6de08d47a4ac213e89a70d7c8f
work_keys_str_mv	AT gcinokwakhedngcobo measurementofserumacestatusmaypotentiallyimprovethediagnosisofsarscov2infection
_version_	1718415999843172352

Measurement of serum ACE status may potentially improve the diagnosis of SARS-CoV-2 infection

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