Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus

Henrique Machado et al. describe mutational mechanisms associated with MRSA vancomycin resistance in Staphylococcus aureus using adaptive laboratory evolution experiments focused on tolerance. Their results reveal environment-dependent mutational strategies to vancomycin tolerization and the impact...

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Autores principales:	Henrique Machado, Yara Seif, George Sakoulas, Connor A. Olson, Ying Hefner, Amitesh Anand, Ying Z. Jones, Richard Szubin, Bernhard O. Palsson, Victor Nizet, Adam M. Feist
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c389d118dc5044379b2f7e0d3dda2b45
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spelling	oai:doaj.org-article:c389d118dc5044379b2f7e0d3dda2b452021-12-02T17:44:54ZEnvironmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus10.1038/s42003-021-02339-z2399-3642https://doaj.org/article/c389d118dc5044379b2f7e0d3dda2b452021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02339-zhttps://doaj.org/toc/2399-3642Henrique Machado et al. describe mutational mechanisms associated with MRSA vancomycin resistance in Staphylococcus aureus using adaptive laboratory evolution experiments focused on tolerance. Their results reveal environment-dependent mutational strategies to vancomycin tolerization and the impact of mutations in regulatory genes, providing insight into the development of antibiotic resistance under multiple conditions.Henrique MachadoYara SeifGeorge SakoulasConnor A. OlsonYing HefnerAmitesh AnandYing Z. JonesRichard SzubinBernhard O. PalssonVictor NizetAdam M. FeistNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Henrique Machado Yara Seif George Sakoulas Connor A. Olson Ying Hefner Amitesh Anand Ying Z. Jones Richard Szubin Bernhard O. Palsson Victor Nizet Adam M. Feist Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus
description	Henrique Machado et al. describe mutational mechanisms associated with MRSA vancomycin resistance in Staphylococcus aureus using adaptive laboratory evolution experiments focused on tolerance. Their results reveal environment-dependent mutational strategies to vancomycin tolerization and the impact of mutations in regulatory genes, providing insight into the development of antibiotic resistance under multiple conditions.
format	article
author	Henrique Machado Yara Seif George Sakoulas Connor A. Olson Ying Hefner Amitesh Anand Ying Z. Jones Richard Szubin Bernhard O. Palsson Victor Nizet Adam M. Feist
author_facet	Henrique Machado Yara Seif George Sakoulas Connor A. Olson Ying Hefner Amitesh Anand Ying Z. Jones Richard Szubin Bernhard O. Palsson Victor Nizet Adam M. Feist
author_sort	Henrique Machado
title	Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus
title_short	Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus
title_full	Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus
title_fullStr	Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus
title_full_unstemmed	Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus
title_sort	environmental conditions dictate differential evolution of vancomycin resistance in staphylococcus aureus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c389d118dc5044379b2f7e0d3dda2b45
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Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus

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