Tissue specific diversification, virulence and immune response to Mycobacterium bovis BCG in a patient with an IFN-γ R1 deficiency

Tissue specific diversification, virulence and immune response to Mycobacterium bovis BCG in a patient with an IFN-γ R1 deficiency

Summary: We characterized Mycobacterium bovis BCG isolates found in lung and brain samples from a previously vaccinated patient with IFNγR1 deficiency. The isolates collected displayed distinct genomic and phenotypic features consistent with host adaptation and associated changes in antibiotic susce...

Full description

Saved in:
Bibliographic Details
Main Authors: Cecilia B. Korol, Shamira J. Shallom, Kriti Arora, Helena I. Boshoff, Alexandra F. Freeman, Alejandra King, Sonia Agrawal, Sean C. Daugherty, Timothy Jancel, Juraj Kabat, Sundar Ganesan, Marina N. Torrero, Elizabeth P. Sampaio, Clifton Barry, Steve M Holland, Hervé Tettelin, Sergio D Rosenzweig, Adrian M. Zelazny
Format: article
Language:EN
Published: Taylor & Francis Group 2020
Subjects:
tuberculosis
bcg
antibiotic resistance
immunodeficiency
mendelian susceptibility to mycobacterial diseases
interferon-γ
Infectious and parasitic diseases
RC109-216
Online Access:https://doaj.org/article/c389e6b7ad754220ad0f5defb0a60810
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/c389e6b7ad754220ad0f5defb0a60810

Similar Items