Tissue specific diversification, virulence and immune response to Mycobacterium bovis BCG in a patient with an IFN-γ R1 deficiency

Summary: We characterized Mycobacterium bovis BCG isolates found in lung and brain samples from a previously vaccinated patient with IFNγR1 deficiency. The isolates collected displayed distinct genomic and phenotypic features consistent with host adaptation and associated changes in antibiotic susce...

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Auteurs principaux:	Cecilia B. Korol, Shamira J. Shallom, Kriti Arora, Helena I. Boshoff, Alexandra F. Freeman, Alejandra King, Sonia Agrawal, Sean C. Daugherty, Timothy Jancel, Juraj Kabat, Sundar Ganesan, Marina N. Torrero, Elizabeth P. Sampaio, Clifton Barry, Steve M Holland, Hervé Tettelin, Sergio D Rosenzweig, Adrian M. Zelazny
Format:	article
Langue:	EN
Publié:	Taylor & Francis Group 2020
Sujets:	tuberculosis bcg antibiotic resistance immunodeficiency mendelian susceptibility to mycobacterial diseases interferon-γ Infectious and parasitic diseases RC109-216
Accès en ligne:	https://doaj.org/article/c389e6b7ad754220ad0f5defb0a60810
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Tissue specific diversification, virulence and immune response to Mycobacterium bovis BCG in a patient with an IFN-γ R1 deficiency

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