Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice

Nakamura et al. used expression studies to identify an enrichment of Zfhx4 in cartilage and revealed through global gene knock-down that it is required for proper endochondral ossification in mice. They further demonstrated a physical and genetic interaction between Zfhx4 and Osterix, which is of in...

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Autores principales:	Eriko Nakamura, Kenji Hata, Yoshifumi Takahata, Hiroshi Kurosaka, Makoto Abe, Takaya Abe, Miho Kihara, Toshihisa Komori, Sachi Kobayashi, Tomohiko Murakami, Toshihiro Inubushi, Takashi Yamashiro, Shiori Yamamoto, Haruhiko Akiyama, Makoto Kawaguchi, Nobuo Sakata, Riko Nishimura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c38c2a6d2d8844b3af9e0bfa858e2f81
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spelling	oai:doaj.org-article:c38c2a6d2d8844b3af9e0bfa858e2f812021-11-07T12:20:04ZZfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice10.1038/s42003-021-02793-92399-3642https://doaj.org/article/c38c2a6d2d8844b3af9e0bfa858e2f812021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02793-9https://doaj.org/toc/2399-3642Nakamura et al. used expression studies to identify an enrichment of Zfhx4 in cartilage and revealed through global gene knock-down that it is required for proper endochondral ossification in mice. They further demonstrated a physical and genetic interaction between Zfhx4 and Osterix, which is of interest to the field of transcriptional regulation of mammalian endochondral ossification.Eriko NakamuraKenji HataYoshifumi TakahataHiroshi KurosakaMakoto AbeTakaya AbeMiho KiharaToshihisa KomoriSachi KobayashiTomohiko MurakamiToshihiro InubushiTakashi YamashiroShiori YamamotoHaruhiko AkiyamaMakoto KawaguchiNobuo SakataRiko NishimuraNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Eriko Nakamura Kenji Hata Yoshifumi Takahata Hiroshi Kurosaka Makoto Abe Takaya Abe Miho Kihara Toshihisa Komori Sachi Kobayashi Tomohiko Murakami Toshihiro Inubushi Takashi Yamashiro Shiori Yamamoto Haruhiko Akiyama Makoto Kawaguchi Nobuo Sakata Riko Nishimura Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice
description	Nakamura et al. used expression studies to identify an enrichment of Zfhx4 in cartilage and revealed through global gene knock-down that it is required for proper endochondral ossification in mice. They further demonstrated a physical and genetic interaction between Zfhx4 and Osterix, which is of interest to the field of transcriptional regulation of mammalian endochondral ossification.
format	article
author	Eriko Nakamura Kenji Hata Yoshifumi Takahata Hiroshi Kurosaka Makoto Abe Takaya Abe Miho Kihara Toshihisa Komori Sachi Kobayashi Tomohiko Murakami Toshihiro Inubushi Takashi Yamashiro Shiori Yamamoto Haruhiko Akiyama Makoto Kawaguchi Nobuo Sakata Riko Nishimura
author_facet	Eriko Nakamura Kenji Hata Yoshifumi Takahata Hiroshi Kurosaka Makoto Abe Takaya Abe Miho Kihara Toshihisa Komori Sachi Kobayashi Tomohiko Murakami Toshihiro Inubushi Takashi Yamashiro Shiori Yamamoto Haruhiko Akiyama Makoto Kawaguchi Nobuo Sakata Riko Nishimura
author_sort	Eriko Nakamura
title	Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice
title_short	Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice
title_full	Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice
title_fullStr	Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice
title_full_unstemmed	Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice
title_sort	zfhx4 regulates endochondral ossification as the transcriptional platform of osterix in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c38c2a6d2d8844b3af9e0bfa858e2f81
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Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice

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