MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates

MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates

Matching iPSC donors’ and patients’ HLA haplotypes has been proposed as a way to generate cell therapy products with enhanced immunological compatibility. Here the authors show that MHC matching alone is insufficient to grant long-term survival of neuronal grafts in the lesioned brain of non-human p...

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Autores principales: Romina Aron Badin, Aurore Bugi, Susannah Williams, Marta Vadori, Marie Michael, Caroline Jan, Alberto Nassi, Sophie Lecourtois, Antoine Blancher, Emanuele Cozzi, Philippe Hantraye, Anselme L. Perrier
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/c38f707228a749deb5410c466af92cb5
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spelling oai:doaj.org-article:c38f707228a749deb5410c466af92cb52021-12-02T16:57:35ZMHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates10.1038/s41467-019-12324-02041-1723https://doaj.org/article/c38f707228a749deb5410c466af92cb52019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12324-0https://doaj.org/toc/2041-1723Matching iPSC donors’ and patients’ HLA haplotypes has been proposed as a way to generate cell therapy products with enhanced immunological compatibility. Here the authors show that MHC matching alone is insufficient to grant long-term survival of neuronal grafts in the lesioned brain of non-human primates.Romina Aron BadinAurore BugiSusannah WilliamsMarta VadoriMarie MichaelCaroline JanAlberto NassiSophie LecourtoisAntoine BlancherEmanuele CozziPhilippe HantrayeAnselme L. PerrierNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Romina Aron Badin
Aurore Bugi
Susannah Williams
Marta Vadori
Marie Michael
Caroline Jan
Alberto Nassi
Sophie Lecourtois
Antoine Blancher
Emanuele Cozzi
Philippe Hantraye
Anselme L. Perrier
MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates
description Matching iPSC donors’ and patients’ HLA haplotypes has been proposed as a way to generate cell therapy products with enhanced immunological compatibility. Here the authors show that MHC matching alone is insufficient to grant long-term survival of neuronal grafts in the lesioned brain of non-human primates.
format article
author Romina Aron Badin
Aurore Bugi
Susannah Williams
Marta Vadori
Marie Michael
Caroline Jan
Alberto Nassi
Sophie Lecourtois
Antoine Blancher
Emanuele Cozzi
Philippe Hantraye
Anselme L. Perrier
author_facet Romina Aron Badin
Aurore Bugi
Susannah Williams
Marta Vadori
Marie Michael
Caroline Jan
Alberto Nassi
Sophie Lecourtois
Antoine Blancher
Emanuele Cozzi
Philippe Hantraye
Anselme L. Perrier
author_sort Romina Aron Badin
title MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates
title_short MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates
title_full MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates
title_fullStr MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates
title_full_unstemmed MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates
title_sort mhc matching fails to prevent long-term rejection of ipsc-derived neurons in non-human primates
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/c38f707228a749deb5410c466af92cb5
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