Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions

Pranam Chatterjee et al. present a novel computational platform for engineering peptide fusions that bind to the SARS-CoV-2 spike protein and tag it for proteasomal degradation. They experimentally validate an optimal variant in human cells, showing that it inhibits production of infection-competent...

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Autores principales:	Pranam Chatterjee, Manvitha Ponnapati, Christian Kramme, Alexandru M. Plesa, George M. Church, Joseph M. Jacobson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c38f96c2ae5f4bc7940b60f8c64fa945
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spelling	oai:doaj.org-article:c38f96c2ae5f4bc7940b60f8c64fa9452021-12-02T12:30:42ZTargeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions10.1038/s42003-020-01470-72399-3642https://doaj.org/article/c38f96c2ae5f4bc7940b60f8c64fa9452020-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01470-7https://doaj.org/toc/2399-3642Pranam Chatterjee et al. present a novel computational platform for engineering peptide fusions that bind to the SARS-CoV-2 spike protein and tag it for proteasomal degradation. They experimentally validate an optimal variant in human cells, showing that it inhibits production of infection-competent virus.Pranam ChatterjeeManvitha PonnapatiChristian KrammeAlexandru M. PlesaGeorge M. ChurchJoseph M. JacobsonNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Pranam Chatterjee Manvitha Ponnapati Christian Kramme Alexandru M. Plesa George M. Church Joseph M. Jacobson Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions
description	Pranam Chatterjee et al. present a novel computational platform for engineering peptide fusions that bind to the SARS-CoV-2 spike protein and tag it for proteasomal degradation. They experimentally validate an optimal variant in human cells, showing that it inhibits production of infection-competent virus.
format	article
author	Pranam Chatterjee Manvitha Ponnapati Christian Kramme Alexandru M. Plesa George M. Church Joseph M. Jacobson
author_facet	Pranam Chatterjee Manvitha Ponnapati Christian Kramme Alexandru M. Plesa George M. Church Joseph M. Jacobson
author_sort	Pranam Chatterjee
title	Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions
title_short	Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions
title_full	Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions
title_fullStr	Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions
title_full_unstemmed	Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions
title_sort	targeted intracellular degradation of sars-cov-2 via computationally optimized peptide fusions
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c38f96c2ae5f4bc7940b60f8c64fa945
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Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions

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