Effects of the mode of re-socialization after juvenile social isolation on medial prefrontal cortex myelination and function

Abstract Social isolation is an important factor in the development of psychiatric disorders. It is necessary to develop an effective psychological treatment, such as cognitive rehabilitation, for children who have already suffered from social isolation, such as neglect and social rejection. We used...

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Autores principales:	Manabu Makinodan, Daisuke Ikawa, Kazuhiko Yamamuro, Yasunori Yamashita, Michihiro Toritsuka, Sohei Kimoto, Takahira Yamauchi, Kazuki Okumura, Takashi Komori, Shin-ichi Fukami, Hiroki Yoshino, Shigenobu Kanba, Akio Wanaka, Toshifumi Kishimoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c39060ba5fae40cba5473af9a2eb09b9
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spelling	oai:doaj.org-article:c39060ba5fae40cba5473af9a2eb09b92021-12-02T16:08:19ZEffects of the mode of re-socialization after juvenile social isolation on medial prefrontal cortex myelination and function10.1038/s41598-017-05632-22045-2322https://doaj.org/article/c39060ba5fae40cba5473af9a2eb09b92017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05632-2https://doaj.org/toc/2045-2322Abstract Social isolation is an important factor in the development of psychiatric disorders. It is necessary to develop an effective psychological treatment, such as cognitive rehabilitation, for children who have already suffered from social isolation, such as neglect and social rejection. We used socially isolated mice to validate whether elaborate re-socialization after juvenile social isolation can restore hypomyelination in the medial prefrontal cortex (mPFC) and the attendant functions manifested in socially isolated mice. While mice who underwent re-socialization with socially isolated mice after juvenile social isolation (Re-IS mice) demonstrated less mPFC activity during exposure to a strange mouse, as well as thinner myelin in the mPFC than controls, mice who underwent re-socialization with socially housed mice after juvenile social isolation (Re-SH mice) caught up with the controls in terms of most mPFC functions, as well as myelination. Moreover, social interaction of Re-IS mice was reduced as compared to controls, but Re-SH mice showed an amount of social interaction comparable to that of controls. These results suggest that the mode of re-socialization after juvenile social isolation has significant effects on myelination in the mPFC and the attendant functions in mice, indicating the importance of appropriate psychosocial intervention after social isolation.Manabu MakinodanDaisuke IkawaKazuhiko YamamuroYasunori YamashitaMichihiro ToritsukaSohei KimotoTakahira YamauchiKazuki OkumuraTakashi KomoriShin-ichi FukamiHiroki YoshinoShigenobu KanbaAkio WanakaToshifumi KishimotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manabu Makinodan Daisuke Ikawa Kazuhiko Yamamuro Yasunori Yamashita Michihiro Toritsuka Sohei Kimoto Takahira Yamauchi Kazuki Okumura Takashi Komori Shin-ichi Fukami Hiroki Yoshino Shigenobu Kanba Akio Wanaka Toshifumi Kishimoto Effects of the mode of re-socialization after juvenile social isolation on medial prefrontal cortex myelination and function
description	Abstract Social isolation is an important factor in the development of psychiatric disorders. It is necessary to develop an effective psychological treatment, such as cognitive rehabilitation, for children who have already suffered from social isolation, such as neglect and social rejection. We used socially isolated mice to validate whether elaborate re-socialization after juvenile social isolation can restore hypomyelination in the medial prefrontal cortex (mPFC) and the attendant functions manifested in socially isolated mice. While mice who underwent re-socialization with socially isolated mice after juvenile social isolation (Re-IS mice) demonstrated less mPFC activity during exposure to a strange mouse, as well as thinner myelin in the mPFC than controls, mice who underwent re-socialization with socially housed mice after juvenile social isolation (Re-SH mice) caught up with the controls in terms of most mPFC functions, as well as myelination. Moreover, social interaction of Re-IS mice was reduced as compared to controls, but Re-SH mice showed an amount of social interaction comparable to that of controls. These results suggest that the mode of re-socialization after juvenile social isolation has significant effects on myelination in the mPFC and the attendant functions in mice, indicating the importance of appropriate psychosocial intervention after social isolation.
format	article
author	Manabu Makinodan Daisuke Ikawa Kazuhiko Yamamuro Yasunori Yamashita Michihiro Toritsuka Sohei Kimoto Takahira Yamauchi Kazuki Okumura Takashi Komori Shin-ichi Fukami Hiroki Yoshino Shigenobu Kanba Akio Wanaka Toshifumi Kishimoto
author_facet	Manabu Makinodan Daisuke Ikawa Kazuhiko Yamamuro Yasunori Yamashita Michihiro Toritsuka Sohei Kimoto Takahira Yamauchi Kazuki Okumura Takashi Komori Shin-ichi Fukami Hiroki Yoshino Shigenobu Kanba Akio Wanaka Toshifumi Kishimoto
author_sort	Manabu Makinodan
title	Effects of the mode of re-socialization after juvenile social isolation on medial prefrontal cortex myelination and function
title_short	Effects of the mode of re-socialization after juvenile social isolation on medial prefrontal cortex myelination and function
title_full	Effects of the mode of re-socialization after juvenile social isolation on medial prefrontal cortex myelination and function
title_fullStr	Effects of the mode of re-socialization after juvenile social isolation on medial prefrontal cortex myelination and function
title_full_unstemmed	Effects of the mode of re-socialization after juvenile social isolation on medial prefrontal cortex myelination and function
title_sort	effects of the mode of re-socialization after juvenile social isolation on medial prefrontal cortex myelination and function
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c39060ba5fae40cba5473af9a2eb09b9
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Effects of the mode of re-socialization after juvenile social isolation on medial prefrontal cortex myelination and function

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