Therapeutic effectiveness of Ocimum basilicum extract on bovine cutaneous papillomatosis
Bovine cutaneous papillomatosis is a common cutaneous disease of cattle in the Egyptian veterinary field. Ocimum basilicum L. (Rehan) is one of the aromatic plants originating in Asia and Africa. Many studies showed that Ocimum basilicum has interesting antiviral and anticancer activities. However...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
South Valley University
2020
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/c3907297413443dbb077f66c9414bcd5 |
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| Sumario: | Bovine cutaneous papillomatosis is a common cutaneous disease of cattle in the Egyptian veterinary
field. Ocimum basilicum L. (Rehan) is one of the aromatic plants originating in Asia and Africa. Many
studies showed that Ocimum basilicum has interesting antiviral and anticancer activities. However, there
is no report demonstrating the clinical significance of the anti-papilloma activity of Ocimum basilicum
against bovine skin papillomas. Thus, our study was designed to evaluate the therapeutic potential of
Ocimum basilicum extract (OBEx) as an anti-papilloma agent against bovine papillomatosis. OBEx was
prepared and undergone phytochemical analysis that revealed presence of alkaloids, phenolics, and
flavonoids. Ten cutaneous papillomatosis-infected cattle were diagnosed clinically and
histopathologically. Animals were treated with OBEx ointment 2% that topically applied daily and
papillomas regression was recorded weekly. Clinically, papillomas started to disappear from the 7th
- 21st
day after the start of treatment. Histopathological analysis showed improvement in histological features of
wart tissue returning to the normal skin structure with presence of lymphocytic infiltration. We concluded
that the topical application of OBEx is an effective, promising alternative, cheap, and easily apply agent
for treatment of skin papilloma.
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