Measuring the Flow Functions of Pharmaceutical Powders Using the Brookfield Powder Flow Tester and Freeman FT4

This study examined the feasibility of combining data from different powder flow testers to determine the flow function characteristics of pharmaceutical powders. The Brookfield PFT and Freeman FT4 can measure flow function over different scales of consolidation load but were found to be most comple...

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Autor principal:	Mark Christopher Leaper
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	shear cell flow function pharmaceutical powders cohesion powder compaction Chemical technology TP1-1185 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c3914cd3b90848d3b27ed64f2b3a7e66
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spelling	oai:doaj.org-article:c3914cd3b90848d3b27ed64f2b3a7e662021-11-25T18:51:37ZMeasuring the Flow Functions of Pharmaceutical Powders Using the Brookfield Powder Flow Tester and Freeman FT410.3390/pr91120322227-9717https://doaj.org/article/c3914cd3b90848d3b27ed64f2b3a7e662021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9717/9/11/2032https://doaj.org/toc/2227-9717This study examined the feasibility of combining data from different powder flow testers to determine the flow function characteristics of pharmaceutical powders. The Brookfield PFT and Freeman FT4 can measure flow function over different scales of consolidation load but were found to be most complementary with CRM limestone powder and lactose. The brittle behaviour of Easytab particles at higher loads made obtaining repeatable results with the FT4 challenging. By using the method of Wang et al., where the flow function coefficient <i>ffc</i> is plotted against the dimensionless cohesion <i>C*</i> (measured cohesion <i>T<sub>a</sub></i> divided by the initial compaction <i>I</i>), a plot was formed which could be used to predict the behaviour of other systems, which compared well with previous studies.Mark Christopher LeaperMDPI AGarticleshear cellflow functionpharmaceutical powderscohesionpowder compactionChemical technologyTP1-1185ChemistryQD1-999ENProcesses, Vol 9, Iss 2032, p 2032 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	shear cell flow function pharmaceutical powders cohesion powder compaction Chemical technology TP1-1185 Chemistry QD1-999
spellingShingle	shear cell flow function pharmaceutical powders cohesion powder compaction Chemical technology TP1-1185 Chemistry QD1-999 Mark Christopher Leaper Measuring the Flow Functions of Pharmaceutical Powders Using the Brookfield Powder Flow Tester and Freeman FT4
description	This study examined the feasibility of combining data from different powder flow testers to determine the flow function characteristics of pharmaceutical powders. The Brookfield PFT and Freeman FT4 can measure flow function over different scales of consolidation load but were found to be most complementary with CRM limestone powder and lactose. The brittle behaviour of Easytab particles at higher loads made obtaining repeatable results with the FT4 challenging. By using the method of Wang et al., where the flow function coefficient <i>ffc</i> is plotted against the dimensionless cohesion <i>C*</i> (measured cohesion <i>T<sub>a</sub></i> divided by the initial compaction <i>I</i>), a plot was formed which could be used to predict the behaviour of other systems, which compared well with previous studies.
format	article
author	Mark Christopher Leaper
author_facet	Mark Christopher Leaper
author_sort	Mark Christopher Leaper
title	Measuring the Flow Functions of Pharmaceutical Powders Using the Brookfield Powder Flow Tester and Freeman FT4
title_short	Measuring the Flow Functions of Pharmaceutical Powders Using the Brookfield Powder Flow Tester and Freeman FT4
title_full	Measuring the Flow Functions of Pharmaceutical Powders Using the Brookfield Powder Flow Tester and Freeman FT4
title_fullStr	Measuring the Flow Functions of Pharmaceutical Powders Using the Brookfield Powder Flow Tester and Freeman FT4
title_full_unstemmed	Measuring the Flow Functions of Pharmaceutical Powders Using the Brookfield Powder Flow Tester and Freeman FT4
title_sort	measuring the flow functions of pharmaceutical powders using the brookfield powder flow tester and freeman ft4
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c3914cd3b90848d3b27ed64f2b3a7e66
work_keys_str_mv	AT markchristopherleaper measuringtheflowfunctionsofpharmaceuticalpowdersusingthebrookfieldpowderflowtesterandfreemanft4
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Measuring the Flow Functions of Pharmaceutical Powders Using the Brookfield Powder Flow Tester and Freeman FT4

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