Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk

The authors provide a comprehensive, single base resolution view of association between genetic variation and DNA methylation in human brain. They also show that heritability attributed to schizophrenia GWAS-associated variants reflects the epigenetic plasticity of the brain.

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Autores principales:	Kira A. Perzel Mandell, Nicholas J. Eagles, Richard Wilton, Amanda J. Price, Stephen A. Semick, Leonardo Collado-Torres, William S. Ulrich, Ran Tao, Shizhong Han, Alexander S. Szalay, Thomas M. Hyde, Joel E. Kleinman, Daniel R. Weinberger, Andrew E. Jaffe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c39209296bd643a888732cfc9a82670a
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spelling	oai:doaj.org-article:c39209296bd643a888732cfc9a82670a2021-12-02T15:26:52ZGenome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk10.1038/s41467-021-25517-32041-1723https://doaj.org/article/c39209296bd643a888732cfc9a82670a2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25517-3https://doaj.org/toc/2041-1723The authors provide a comprehensive, single base resolution view of association between genetic variation and DNA methylation in human brain. They also show that heritability attributed to schizophrenia GWAS-associated variants reflects the epigenetic plasticity of the brain.Kira A. Perzel MandellNicholas J. EaglesRichard WiltonAmanda J. PriceStephen A. SemickLeonardo Collado-TorresWilliam S. UlrichRan TaoShizhong HanAlexander S. SzalayThomas M. HydeJoel E. KleinmanDaniel R. WeinbergerAndrew E. JaffeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kira A. Perzel Mandell Nicholas J. Eagles Richard Wilton Amanda J. Price Stephen A. Semick Leonardo Collado-Torres William S. Ulrich Ran Tao Shizhong Han Alexander S. Szalay Thomas M. Hyde Joel E. Kleinman Daniel R. Weinberger Andrew E. Jaffe Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk
description	The authors provide a comprehensive, single base resolution view of association between genetic variation and DNA methylation in human brain. They also show that heritability attributed to schizophrenia GWAS-associated variants reflects the epigenetic plasticity of the brain.
format	article
author	Kira A. Perzel Mandell Nicholas J. Eagles Richard Wilton Amanda J. Price Stephen A. Semick Leonardo Collado-Torres William S. Ulrich Ran Tao Shizhong Han Alexander S. Szalay Thomas M. Hyde Joel E. Kleinman Daniel R. Weinberger Andrew E. Jaffe
author_facet	Kira A. Perzel Mandell Nicholas J. Eagles Richard Wilton Amanda J. Price Stephen A. Semick Leonardo Collado-Torres William S. Ulrich Ran Tao Shizhong Han Alexander S. Szalay Thomas M. Hyde Joel E. Kleinman Daniel R. Weinberger Andrew E. Jaffe
author_sort	Kira A. Perzel Mandell
title	Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk
title_short	Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk
title_full	Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk
title_fullStr	Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk
title_full_unstemmed	Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk
title_sort	genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c39209296bd643a888732cfc9a82670a
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Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk

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