Induction of prolonged natural lifespans in mice exposed to acoustic environmental enrichment

Abstract We investigated the effect of acoustic environmental enrichment (EE) on the lifespans and behaviours of mice to the end of their natural lifespan in different acoustic environments. Acoustic EE induced a significantly prolonged natural lifespan (nearly 17% longer) and was associated with in...

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Autores principales:	Yuichi Yamashita, Norie Kawai, Osamu Ueno, Yui Matsumoto, Tsutomu Oohashi, Manabu Honda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c395028cbce54934849142572a22414c
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spelling	oai:doaj.org-article:c395028cbce54934849142572a22414c2021-12-02T15:09:06ZInduction of prolonged natural lifespans in mice exposed to acoustic environmental enrichment10.1038/s41598-018-26302-x2045-2322https://doaj.org/article/c395028cbce54934849142572a22414c2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-26302-xhttps://doaj.org/toc/2045-2322Abstract We investigated the effect of acoustic environmental enrichment (EE) on the lifespans and behaviours of mice to the end of their natural lifespan in different acoustic environments. Acoustic EE induced a significantly prolonged natural lifespan (nearly 17% longer) and was associated with increased voluntary movements. However, no correlation between lifespan and voluntary movements was detected, suggesting that increased voluntary movements are not a primary cause of lifespan prolongation. Analyses of individual differences in lifespan demonstrated that lifespan extension induced by acoustic EE could be related to changes in social relationships (e.g., reduction of social conflict) among individuals kept within a cage. Therefore, an acoustic component may be an important factor inducing the positive effects of EE.Yuichi YamashitaNorie KawaiOsamu UenoYui MatsumotoTsutomu OohashiManabu HondaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuichi Yamashita Norie Kawai Osamu Ueno Yui Matsumoto Tsutomu Oohashi Manabu Honda Induction of prolonged natural lifespans in mice exposed to acoustic environmental enrichment
description	Abstract We investigated the effect of acoustic environmental enrichment (EE) on the lifespans and behaviours of mice to the end of their natural lifespan in different acoustic environments. Acoustic EE induced a significantly prolonged natural lifespan (nearly 17% longer) and was associated with increased voluntary movements. However, no correlation between lifespan and voluntary movements was detected, suggesting that increased voluntary movements are not a primary cause of lifespan prolongation. Analyses of individual differences in lifespan demonstrated that lifespan extension induced by acoustic EE could be related to changes in social relationships (e.g., reduction of social conflict) among individuals kept within a cage. Therefore, an acoustic component may be an important factor inducing the positive effects of EE.
format	article
author	Yuichi Yamashita Norie Kawai Osamu Ueno Yui Matsumoto Tsutomu Oohashi Manabu Honda
author_facet	Yuichi Yamashita Norie Kawai Osamu Ueno Yui Matsumoto Tsutomu Oohashi Manabu Honda
author_sort	Yuichi Yamashita
title	Induction of prolonged natural lifespans in mice exposed to acoustic environmental enrichment
title_short	Induction of prolonged natural lifespans in mice exposed to acoustic environmental enrichment
title_full	Induction of prolonged natural lifespans in mice exposed to acoustic environmental enrichment
title_fullStr	Induction of prolonged natural lifespans in mice exposed to acoustic environmental enrichment
title_full_unstemmed	Induction of prolonged natural lifespans in mice exposed to acoustic environmental enrichment
title_sort	induction of prolonged natural lifespans in mice exposed to acoustic environmental enrichment
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c395028cbce54934849142572a22414c
work_keys_str_mv	AT yuichiyamashita inductionofprolongednaturallifespansinmiceexposedtoacousticenvironmentalenrichment AT noriekawai inductionofprolongednaturallifespansinmiceexposedtoacousticenvironmentalenrichment AT osamuueno inductionofprolongednaturallifespansinmiceexposedtoacousticenvironmentalenrichment AT yuimatsumoto inductionofprolongednaturallifespansinmiceexposedtoacousticenvironmentalenrichment AT tsutomuoohashi inductionofprolongednaturallifespansinmiceexposedtoacousticenvironmentalenrichment AT manabuhonda inductionofprolongednaturallifespansinmiceexposedtoacousticenvironmentalenrichment
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Induction of prolonged natural lifespans in mice exposed to acoustic environmental enrichment

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