Development of ciprofloxacin sensor using iron-doped graphitic carbon nitride as transducer matrix: Analysis of ciprofloxacin in blood samples

In the present work, we have synthesized an iron-decorated graphitic carbon nitride (Fe@g-C3N4) composite and employed it for electrochemical sensing of ciprofloxacin (CFX). The physicochemical characteristics of the Fe@g-C3N4 composite were analyzed with X-ray diffraction (XRD), scanning electron...

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Autores principales:	Hattna Shivarudraiah Vedhavathi, Ballur Prasanna Sanjay, Mahesh Basavaraju, Beejaganahalli Sangameshwara Madhukar, Ningappa Kumara Swamy
Formato:	article
Lenguaje:	EN
Publicado:	International Association of Physical Chemists (IAPC) 2021
Materias:	quinolone drug sensor electrochemical sensor electrode matrix differential pulse voltammetry Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c3961dc4e1524313a85b1884cef910d1
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spelling	oai:doaj.org-article:c3961dc4e1524313a85b1884cef910d12021-11-18T10:07:26ZDevelopment of ciprofloxacin sensor using iron-doped graphitic carbon nitride as transducer matrix: Analysis of ciprofloxacin in blood samples10.5599/jese.11121847-9286https://doaj.org/article/c3961dc4e1524313a85b1884cef910d12021-11-01T00:00:00Zhttp://pub.iapchem.org/ojs/index.php/JESE/article/view/1112https://doaj.org/toc/1847-9286 In the present work, we have synthesized an iron-decorated graphitic carbon nitride (Fe@g-C3N4) composite and employed it for electrochemical sensing of ciprofloxacin (CFX). The physicochemical characteristics of the Fe@g-C3N4 composite were analyzed with X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray diffraction (EDX) spectroscopy methods. Further, the pencil graphite electrode (PGE) was modified with Fe@g-C3N4 composite to get PGE/Fe@g-C3N4 electrode and characterized the resultant electrode by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Differential pulse voltammetry (DPV) was employed to determine the effect of concentration and interferents. The modified PGE/Fe@g-C3N4 electrode demonstrated the exceptional electrochemical performance for CFX identification and quantification with a LOD of 5.4 nM, a wide linear range of 0.001-1.0 µM, and high sensitivity of 0.0018 µA mM-1 cm-2. Besides, Fe@g-C3N4 modified PGE showed remarkable recovery results in qualitative analysis of CFX in human blood specimens. This research advocates that the Fe@g-C3N4 composite acts as an excellent transducer material in the electrochemical sensing of CFX in blood and standard samples. Further, the proposed strategy deduces that the PGE/Fe@g-C3N4 sensor can be a prospective candidate for the dynamic determination of CFX in blood serum and possibly ratified as an exceptional drug sensor for therapeutic purposes. Hattna Shivarudraiah VedhavathiBallur Prasanna Sanjay Mahesh BasavarajuBeejaganahalli Sangameshwara MadhukarNingappa Kumara SwamyInternational Association of Physical Chemists (IAPC)articlequinolonedrug sensorelectrochemical sensorelectrode matrixdifferential pulse voltammetryChemistryQD1-999ENJournal of Electrochemical Science and Engineering, Vol 11, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	quinolone drug sensor electrochemical sensor electrode matrix differential pulse voltammetry Chemistry QD1-999
spellingShingle	quinolone drug sensor electrochemical sensor electrode matrix differential pulse voltammetry Chemistry QD1-999 Hattna Shivarudraiah Vedhavathi Ballur Prasanna Sanjay Mahesh Basavaraju Beejaganahalli Sangameshwara Madhukar Ningappa Kumara Swamy Development of ciprofloxacin sensor using iron-doped graphitic carbon nitride as transducer matrix: Analysis of ciprofloxacin in blood samples
description	In the present work, we have synthesized an iron-decorated graphitic carbon nitride (Fe@g-C3N4) composite and employed it for electrochemical sensing of ciprofloxacin (CFX). The physicochemical characteristics of the Fe@g-C3N4 composite were analyzed with X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray diffraction (EDX) spectroscopy methods. Further, the pencil graphite electrode (PGE) was modified with Fe@g-C3N4 composite to get PGE/Fe@g-C3N4 electrode and characterized the resultant electrode by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Differential pulse voltammetry (DPV) was employed to determine the effect of concentration and interferents. The modified PGE/Fe@g-C3N4 electrode demonstrated the exceptional electrochemical performance for CFX identification and quantification with a LOD of 5.4 nM, a wide linear range of 0.001-1.0 µM, and high sensitivity of 0.0018 µA mM-1 cm-2. Besides, Fe@g-C3N4 modified PGE showed remarkable recovery results in qualitative analysis of CFX in human blood specimens. This research advocates that the Fe@g-C3N4 composite acts as an excellent transducer material in the electrochemical sensing of CFX in blood and standard samples. Further, the proposed strategy deduces that the PGE/Fe@g-C3N4 sensor can be a prospective candidate for the dynamic determination of CFX in blood serum and possibly ratified as an exceptional drug sensor for therapeutic purposes.
format	article
author	Hattna Shivarudraiah Vedhavathi Ballur Prasanna Sanjay Mahesh Basavaraju Beejaganahalli Sangameshwara Madhukar Ningappa Kumara Swamy
author_facet	Hattna Shivarudraiah Vedhavathi Ballur Prasanna Sanjay Mahesh Basavaraju Beejaganahalli Sangameshwara Madhukar Ningappa Kumara Swamy
author_sort	Hattna Shivarudraiah Vedhavathi
title	Development of ciprofloxacin sensor using iron-doped graphitic carbon nitride as transducer matrix: Analysis of ciprofloxacin in blood samples
title_short	Development of ciprofloxacin sensor using iron-doped graphitic carbon nitride as transducer matrix: Analysis of ciprofloxacin in blood samples
title_full	Development of ciprofloxacin sensor using iron-doped graphitic carbon nitride as transducer matrix: Analysis of ciprofloxacin in blood samples
title_fullStr	Development of ciprofloxacin sensor using iron-doped graphitic carbon nitride as transducer matrix: Analysis of ciprofloxacin in blood samples
title_full_unstemmed	Development of ciprofloxacin sensor using iron-doped graphitic carbon nitride as transducer matrix: Analysis of ciprofloxacin in blood samples
title_sort	development of ciprofloxacin sensor using iron-doped graphitic carbon nitride as transducer matrix: analysis of ciprofloxacin in blood samples
publisher	International Association of Physical Chemists (IAPC)
publishDate	2021
url	https://doaj.org/article/c3961dc4e1524313a85b1884cef910d1
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Development of ciprofloxacin sensor using iron-doped graphitic carbon nitride as transducer matrix: Analysis of ciprofloxacin in blood samples

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