Levels of thrombopoietin in aqueous humor of patients with noninfectious acute anterior uveitis

José-Juan Mondejar,1,4 David Salom,1,3 Salvador Garcia-Delpech,1,2 Manuel Diaz-Llopis11Ophthalmology Department, School of Medicine, University of Valencia, 2Ophthalmology Department, Hospital Universitario La Fe, 3Ophthalmology Department, Hospital de Manises, Valencia, 4Ophthalmology De...

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Autores principales:	Mondejar JJ, Salom D, Garcia-Delpech S, Diaz-Llopis M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/c396400dff6d46e7b6f46615094601af
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spelling	oai:doaj.org-article:c396400dff6d46e7b6f46615094601af2021-12-02T02:06:13ZLevels of thrombopoietin in aqueous humor of patients with noninfectious acute anterior uveitis1177-5483https://doaj.org/article/c396400dff6d46e7b6f46615094601af2015-07-01T00:00:00Zhttp://www.dovepress.com/levels-of-thrombopoietin-in-aqueous-humor-of-patients-with-noninfectio-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483José-Juan Mondejar,1,4 David Salom,1,3 Salvador Garcia-Delpech,1,2 Manuel Diaz-Llopis11Ophthalmology Department, School of Medicine, University of Valencia, 2Ophthalmology Department, Hospital Universitario La Fe, 3Ophthalmology Department, Hospital de Manises, Valencia, 4Ophthalmology Department, Hospital General Universitario de Alicante, Alicante, SpainPurpose: To measure thrombopoietin (TPO) levels in the serum and aqueous humors of patients with noninfectious acute anterior uveitis.Methods: A prospective, comparative, controlled study. Serum and aqueous humors were obtained from the eyes of 16 patients with noninfectious acute anterior uveitis. TPO levels were measured using an enzyme-linked immunosorbent assay (ELISA). The results obtained were compared with those of a control group.Results: Serum concentrations of TPO were not significantly different between control individuals and patients with active anterior uveitis. Aqueous humor TPO levels were 54.46±16.24 pg/mL in the eyes of patients with uveitis, and 34.32±11.63 pg/mL in the eyes of controls. The difference between the two groups was significant (Mann–Whitney U-test for independent data, P=0.0008), with uveitis patients exhibiting significantly higher levels of TPO. Conclusion: The high levels of TPO in the aqueous humors of uveitis patients points toward a cytoprotective role of this factor in inflammatory repair processes and the recovery of tissue homeostasis.Keywords: TPO, thrombopoietin, aqueous humors, serum, acute anterior uveitis, cytoprotectiveMondejar JJSalom DGarcia-Delpech SDiaz-Llopis MDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 1285-1290 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Mondejar JJ Salom D Garcia-Delpech S Diaz-Llopis M Levels of thrombopoietin in aqueous humor of patients with noninfectious acute anterior uveitis
description	José-Juan Mondejar,1,4 David Salom,1,3 Salvador Garcia-Delpech,1,2 Manuel Diaz-Llopis11Ophthalmology Department, School of Medicine, University of Valencia, 2Ophthalmology Department, Hospital Universitario La Fe, 3Ophthalmology Department, Hospital de Manises, Valencia, 4Ophthalmology Department, Hospital General Universitario de Alicante, Alicante, SpainPurpose: To measure thrombopoietin (TPO) levels in the serum and aqueous humors of patients with noninfectious acute anterior uveitis.Methods: A prospective, comparative, controlled study. Serum and aqueous humors were obtained from the eyes of 16 patients with noninfectious acute anterior uveitis. TPO levels were measured using an enzyme-linked immunosorbent assay (ELISA). The results obtained were compared with those of a control group.Results: Serum concentrations of TPO were not significantly different between control individuals and patients with active anterior uveitis. Aqueous humor TPO levels were 54.46±16.24 pg/mL in the eyes of patients with uveitis, and 34.32±11.63 pg/mL in the eyes of controls. The difference between the two groups was significant (Mann–Whitney U-test for independent data, P=0.0008), with uveitis patients exhibiting significantly higher levels of TPO. Conclusion: The high levels of TPO in the aqueous humors of uveitis patients points toward a cytoprotective role of this factor in inflammatory repair processes and the recovery of tissue homeostasis.Keywords: TPO, thrombopoietin, aqueous humors, serum, acute anterior uveitis, cytoprotective
format	article
author	Mondejar JJ Salom D Garcia-Delpech S Diaz-Llopis M
author_facet	Mondejar JJ Salom D Garcia-Delpech S Diaz-Llopis M
author_sort	Mondejar JJ
title	Levels of thrombopoietin in aqueous humor of patients with noninfectious acute anterior uveitis
title_short	Levels of thrombopoietin in aqueous humor of patients with noninfectious acute anterior uveitis
title_full	Levels of thrombopoietin in aqueous humor of patients with noninfectious acute anterior uveitis
title_fullStr	Levels of thrombopoietin in aqueous humor of patients with noninfectious acute anterior uveitis
title_full_unstemmed	Levels of thrombopoietin in aqueous humor of patients with noninfectious acute anterior uveitis
title_sort	levels of thrombopoietin in aqueous humor of patients with noninfectious acute anterior uveitis
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/c396400dff6d46e7b6f46615094601af
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Levels of thrombopoietin in aqueous humor of patients with noninfectious acute anterior uveitis

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