An engineered Mycoplasma pneumoniae to fight Staphylococcus aureus

Bacterial infections are commonly treated with antimicrobials, but the rise of multi‐drug resistance and the presence of biofilms can compromise treatment efficacy. Recently, new approaches using live bacteria or engineered microorganisms have gained attention in the fight against several diseases....

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Autores principales:	Dominick Matteau, Sébastien Rodrigue
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Biology (General) QH301-705.5 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c39d1954526f40a2b45ffde2547167a4
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spelling	oai:doaj.org-article:c39d1954526f40a2b45ffde2547167a42021-11-11T11:30:47ZAn engineered Mycoplasma pneumoniae to fight Staphylococcus aureus1744-429210.15252/msb.202110574https://doaj.org/article/c39d1954526f40a2b45ffde2547167a42021-10-01T00:00:00Zhttps://doi.org/10.15252/msb.202110574https://doaj.org/toc/1744-4292Bacterial infections are commonly treated with antimicrobials, but the rise of multi‐drug resistance and the presence of biofilms can compromise treatment efficacy. Recently, new approaches using live bacteria or engineered microorganisms have gained attention in the fight against several diseases. In their recent work, Lluch‐Senar and colleagues (Garrido et al, 2021) genetically modified the lung pathogen Mycoplasma pneumoniae to attenuate its virulence and secrete antibiofilm and bactericidal enzymes. Their strategy successfully altered a Staphylococcus aureus biofilm on catheters implanted in mice, providing an additional demonstration of the potential of genetically engineered microorganisms as therapeutic agents.Dominick MatteauSébastien RodrigueWileyarticleBiology (General)QH301-705.5Medicine (General)R5-920ENMolecular Systems Biology, Vol 17, Iss 10, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5 Medicine (General) R5-920
spellingShingle	Biology (General) QH301-705.5 Medicine (General) R5-920 Dominick Matteau Sébastien Rodrigue An engineered Mycoplasma pneumoniae to fight Staphylococcus aureus
description	Bacterial infections are commonly treated with antimicrobials, but the rise of multi‐drug resistance and the presence of biofilms can compromise treatment efficacy. Recently, new approaches using live bacteria or engineered microorganisms have gained attention in the fight against several diseases. In their recent work, Lluch‐Senar and colleagues (Garrido et al, 2021) genetically modified the lung pathogen Mycoplasma pneumoniae to attenuate its virulence and secrete antibiofilm and bactericidal enzymes. Their strategy successfully altered a Staphylococcus aureus biofilm on catheters implanted in mice, providing an additional demonstration of the potential of genetically engineered microorganisms as therapeutic agents.
format	article
author	Dominick Matteau Sébastien Rodrigue
author_facet	Dominick Matteau Sébastien Rodrigue
author_sort	Dominick Matteau
title	An engineered Mycoplasma pneumoniae to fight Staphylococcus aureus
title_short	An engineered Mycoplasma pneumoniae to fight Staphylococcus aureus
title_full	An engineered Mycoplasma pneumoniae to fight Staphylococcus aureus
title_fullStr	An engineered Mycoplasma pneumoniae to fight Staphylococcus aureus
title_full_unstemmed	An engineered Mycoplasma pneumoniae to fight Staphylococcus aureus
title_sort	engineered mycoplasma pneumoniae to fight staphylococcus aureus
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/c39d1954526f40a2b45ffde2547167a4
work_keys_str_mv	AT dominickmatteau anengineeredmycoplasmapneumoniaetofightstaphylococcusaureus AT sebastienrodrigue anengineeredmycoplasmapneumoniaetofightstaphylococcusaureus AT dominickmatteau engineeredmycoplasmapneumoniaetofightstaphylococcusaureus AT sebastienrodrigue engineeredmycoplasmapneumoniaetofightstaphylococcusaureus
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An engineered Mycoplasma pneumoniae to fight Staphylococcus aureus

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