RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage

The BRCA1-PALB2-BRCA2-RAD51 (BRCA1-P) complex is well known to play a fundamental role in DNA repair, but how the complex recruitment is regulated is still a matter of interest. Here the authors reveal mechanistic insights into RNF168 activity being responsible for PALB2 recruitment, through BARD1-B...

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Autores principales:	John J. Krais, Yifan Wang, Pooja Patel, Jayati Basu, Andrea J. Bernhardy, Neil Johnson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c39dd0ce8b4f496a844c3e220df1fbac
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spelling	oai:doaj.org-article:c39dd0ce8b4f496a844c3e220df1fbac2021-12-02T15:10:51ZRNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage10.1038/s41467-021-25346-42041-1723https://doaj.org/article/c39dd0ce8b4f496a844c3e220df1fbac2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25346-4https://doaj.org/toc/2041-1723The BRCA1-PALB2-BRCA2-RAD51 (BRCA1-P) complex is well known to play a fundamental role in DNA repair, but how the complex recruitment is regulated is still a matter of interest. Here the authors reveal mechanistic insights into RNF168 activity being responsible for PALB2 recruitment, through BARD1-BRCA1 during homologous recombination repair.John J. KraisYifan WangPooja PatelJayati BasuAndrea J. BernhardyNeil JohnsonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q John J. Krais Yifan Wang Pooja Patel Jayati Basu Andrea J. Bernhardy Neil Johnson RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage
description	The BRCA1-PALB2-BRCA2-RAD51 (BRCA1-P) complex is well known to play a fundamental role in DNA repair, but how the complex recruitment is regulated is still a matter of interest. Here the authors reveal mechanistic insights into RNF168 activity being responsible for PALB2 recruitment, through BARD1-BRCA1 during homologous recombination repair.
format	article
author	John J. Krais Yifan Wang Pooja Patel Jayati Basu Andrea J. Bernhardy Neil Johnson
author_facet	John J. Krais Yifan Wang Pooja Patel Jayati Basu Andrea J. Bernhardy Neil Johnson
author_sort	John J. Krais
title	RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage
title_short	RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage
title_full	RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage
title_fullStr	RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage
title_full_unstemmed	RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage
title_sort	rnf168-mediated localization of bard1 recruits the brca1-palb2 complex to dna damage
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c39dd0ce8b4f496a844c3e220df1fbac
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RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage

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