Correction of Food Hypersensitivity as the Main Principle of Immunodietology in the Treatment of Obesity and Metabolic Disorders

It can be assumed that the reason of failure of classical methods to combat obesity lies in the complete disregard of active involvement of the immune system in the processes of digestion, considering influence of food antigenic load, that is carried by the human body. The new technology Immunodiet...

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Autor principal:	P. S. Novikov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2019
Materias:	food antigens hypersensitivity metabolic syndrome obesity immunodietology Science Q
Acceso en línea:	https://doaj.org/article/c3a02091f39b4c46a9c40c71695e8ea0
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spelling	oai:doaj.org-article:c3a02091f39b4c46a9c40c71695e8ea02021-11-23T06:14:42ZCorrection of Food Hypersensitivity as the Main Principle of Immunodietology in the Treatment of Obesity and Metabolic Disorders2541-94202587-959610.29413/ABS.2019-4.3.2https://doaj.org/article/c3a02091f39b4c46a9c40c71695e8ea02019-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2080https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596It can be assumed that the reason of failure of classical methods to combat obesity lies in the complete disregard of active involvement of the immune system in the processes of digestion, considering influence of food antigenic load, that is carried by the human body. The new technology Immunodietology™, based on a mathematically correct calculation of the individual response of the body’s immune system to food antigens, is a promising trend for modern dietetics in addressing issues of prevention and control of obesity.Aim. To study the features of hypersensitivity to food antigens, as the main trigger of chronic inflammation in the development of obesity and metabolic disorders, to substantiate the personified principles of immunodietology application.Methods. The study of food hypersensitivity was carried out according to the methodology of Immunohealth™. Enzymelinked immunosorbent assay (ELISA) was used for specific IgG to 111 food antigens, distributed over antigenic clusters, to create an individual adaptation diet, based on the mathematically-based criterion “norm – anomaly”. We determined IL-4, IL-6, IL-10, IL-17, TSH, free T3, insulin in serum by means of ELISA.Results. A correlation was established between casein hypersensitivity and an increase in IL-6 concentrations (Rs = 0.30 (p < 0.05)); IL-17 (Rs = 0.32 (p < 0.05)), as well as food hypersensitivity (Type III) to casein and the development of atherogenic changes (OR = 2.7 (1.2; 6.3)).Conclusions. Thus, the results showed that the principles of diagnosis and evaluation, personalized food hypersensitivity are the basis of the new Immunodietology™ technology, which may be a promising trend in modern dietetics to control obesity.P. S. NovikovScientific Сentre for Family Health and Human Reproduction Problemsarticlefood antigenshypersensitivitymetabolic syndromeobesityimmunodietologyScienceQRUActa Biomedica Scientifica, Vol 4, Iss 3, Pp 18-22 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	food antigens hypersensitivity metabolic syndrome obesity immunodietology Science Q
spellingShingle	food antigens hypersensitivity metabolic syndrome obesity immunodietology Science Q P. S. Novikov Correction of Food Hypersensitivity as the Main Principle of Immunodietology in the Treatment of Obesity and Metabolic Disorders
description	It can be assumed that the reason of failure of classical methods to combat obesity lies in the complete disregard of active involvement of the immune system in the processes of digestion, considering influence of food antigenic load, that is carried by the human body. The new technology Immunodietology™, based on a mathematically correct calculation of the individual response of the body’s immune system to food antigens, is a promising trend for modern dietetics in addressing issues of prevention and control of obesity.Aim. To study the features of hypersensitivity to food antigens, as the main trigger of chronic inflammation in the development of obesity and metabolic disorders, to substantiate the personified principles of immunodietology application.Methods. The study of food hypersensitivity was carried out according to the methodology of Immunohealth™. Enzymelinked immunosorbent assay (ELISA) was used for specific IgG to 111 food antigens, distributed over antigenic clusters, to create an individual adaptation diet, based on the mathematically-based criterion “norm – anomaly”. We determined IL-4, IL-6, IL-10, IL-17, TSH, free T3, insulin in serum by means of ELISA.Results. A correlation was established between casein hypersensitivity and an increase in IL-6 concentrations (Rs = 0.30 (p < 0.05)); IL-17 (Rs = 0.32 (p < 0.05)), as well as food hypersensitivity (Type III) to casein and the development of atherogenic changes (OR = 2.7 (1.2; 6.3)).Conclusions. Thus, the results showed that the principles of diagnosis and evaluation, personalized food hypersensitivity are the basis of the new Immunodietology™ technology, which may be a promising trend in modern dietetics to control obesity.
format	article
author	P. S. Novikov
author_facet	P. S. Novikov
author_sort	P. S. Novikov
title	Correction of Food Hypersensitivity as the Main Principle of Immunodietology in the Treatment of Obesity and Metabolic Disorders
title_short	Correction of Food Hypersensitivity as the Main Principle of Immunodietology in the Treatment of Obesity and Metabolic Disorders
title_full	Correction of Food Hypersensitivity as the Main Principle of Immunodietology in the Treatment of Obesity and Metabolic Disorders
title_fullStr	Correction of Food Hypersensitivity as the Main Principle of Immunodietology in the Treatment of Obesity and Metabolic Disorders
title_full_unstemmed	Correction of Food Hypersensitivity as the Main Principle of Immunodietology in the Treatment of Obesity and Metabolic Disorders
title_sort	correction of food hypersensitivity as the main principle of immunodietology in the treatment of obesity and metabolic disorders
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2019
url	https://doaj.org/article/c3a02091f39b4c46a9c40c71695e8ea0
work_keys_str_mv	AT psnovikov correctionoffoodhypersensitivityasthemainprincipleofimmunodietologyinthetreatmentofobesityandmetabolicdisorders
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Correction of Food Hypersensitivity as the Main Principle of Immunodietology in the Treatment of Obesity and Metabolic Disorders

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