AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

AMPK integrates information about a cell’s energy status to inform decisions about cellular processes, including autophagy. Here the authors identify cyclin Y as an AMPK substrate, which phosphorylates cyclin Y and promotes its interaction with CDK16 to stimulate autophagy.

Guardado en:

Detalles Bibliográficos
Autores principales:	Marc Dohmen, Sarah Krieg, Georgios Agalaridis, Xiaoqing Zhu, Saifeldin N. Shehata, Elisabeth Pfeiffenberger, Jan Amelang, Mareike Bütepage, Elena Buerova, Carolina M. Pfaff, Dipanjan Chanda, Stephan Geley, Christian Preisinger, Kei Sakamoto, Bernhard Lüscher, Dietbert Neumann, Jörg Vervoorts
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c3a2cb60cb8f4b428a1b0a25d64f8433
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c3a2cb60cb8f4b428a1b0a25d64f8433
record_format	dspace
spelling	oai:doaj.org-article:c3a2cb60cb8f4b428a1b0a25d64f84332021-12-02T14:41:27ZAMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy10.1038/s41467-020-14812-02041-1723https://doaj.org/article/c3a2cb60cb8f4b428a1b0a25d64f84332020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14812-0https://doaj.org/toc/2041-1723AMPK integrates information about a cell’s energy status to inform decisions about cellular processes, including autophagy. Here the authors identify cyclin Y as an AMPK substrate, which phosphorylates cyclin Y and promotes its interaction with CDK16 to stimulate autophagy.Marc DohmenSarah KriegGeorgios AgalaridisXiaoqing ZhuSaifeldin N. ShehataElisabeth PfeiffenbergerJan AmelangMareike BütepageElena BuerovaCarolina M. PfaffDipanjan ChandaStephan GeleyChristian PreisingerKei SakamotoBernhard LüscherDietbert NeumannJörg VervoortsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marc Dohmen Sarah Krieg Georgios Agalaridis Xiaoqing Zhu Saifeldin N. Shehata Elisabeth Pfeiffenberger Jan Amelang Mareike Bütepage Elena Buerova Carolina M. Pfaff Dipanjan Chanda Stephan Geley Christian Preisinger Kei Sakamoto Bernhard Lüscher Dietbert Neumann Jörg Vervoorts AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
description	AMPK integrates information about a cell’s energy status to inform decisions about cellular processes, including autophagy. Here the authors identify cyclin Y as an AMPK substrate, which phosphorylates cyclin Y and promotes its interaction with CDK16 to stimulate autophagy.
format	article
author	Marc Dohmen Sarah Krieg Georgios Agalaridis Xiaoqing Zhu Saifeldin N. Shehata Elisabeth Pfeiffenberger Jan Amelang Mareike Bütepage Elena Buerova Carolina M. Pfaff Dipanjan Chanda Stephan Geley Christian Preisinger Kei Sakamoto Bernhard Lüscher Dietbert Neumann Jörg Vervoorts
author_facet	Marc Dohmen Sarah Krieg Georgios Agalaridis Xiaoqing Zhu Saifeldin N. Shehata Elisabeth Pfeiffenberger Jan Amelang Mareike Bütepage Elena Buerova Carolina M. Pfaff Dipanjan Chanda Stephan Geley Christian Preisinger Kei Sakamoto Bernhard Lüscher Dietbert Neumann Jörg Vervoorts
author_sort	Marc Dohmen
title	AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
title_short	AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
title_full	AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
title_fullStr	AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
title_full_unstemmed	AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
title_sort	ampk-dependent activation of the cyclin y/cdk16 complex controls autophagy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c3a2cb60cb8f4b428a1b0a25d64f8433
work_keys_str_mv	AT marcdohmen ampkdependentactivationofthecyclinycdk16complexcontrolsautophagy AT sarahkrieg ampkdependentactivationofthecyclinycdk16complexcontrolsautophagy AT georgiosagalaridis ampkdependentactivationofthecyclinycdk16complexcontrolsautophagy AT xiaoqingzhu ampkdependentactivationofthecyclinycdk16complexcontrolsautophagy AT saifeldinnshehata ampkdependentactivationofthecyclinycdk16complexcontrolsautophagy AT elisabethpfeiffenberger ampkdependentactivationofthecyclinycdk16complexcontrolsautophagy AT janamelang ampkdependentactivationofthecyclinycdk16complexcontrolsautophagy AT mareikebutepage ampkdependentactivationofthecyclinycdk16complexcontrolsautophagy AT elenabuerova ampkdependentactivationofthecyclinycdk16complexcontrolsautophagy AT carolinampfaff ampkdependentactivationofthecyclinycdk16complexcontrolsautophagy AT dipanjanchanda ampkdependentactivationofthecyclinycdk16complexcontrolsautophagy AT stephangeley ampkdependentactivationofthecyclinycdk16complexcontrolsautophagy AT christianpreisinger ampkdependentactivationofthecyclinycdk16complexcontrolsautophagy AT keisakamoto ampkdependentactivationofthecyclinycdk16complexcontrolsautophagy AT bernhardluscher ampkdependentactivationofthecyclinycdk16complexcontrolsautophagy AT dietbertneumann ampkdependentactivationofthecyclinycdk16complexcontrolsautophagy AT jorgvervoorts ampkdependentactivationofthecyclinycdk16complexcontrolsautophagy
_version_	1718389896081571840

AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

Ejemplares similares