Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways

The role of the transcriptional effector SMAD4 in vertebrate embryo development remains unresolved. Here the authors show that in the absence of Smad4, dorsal/ventral embryo patterning is disrupted due to the loss of BMP signaling, while Nodal signaling is maintained, but insufficient for optimal en...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Luca Guglielmi, Claire Heliot, Sunil Kumar, Yuriy Alexandrov, Ilaria Gori, Foteini Papaleonidopoulou, Christopher Barrington, Philip East, Andrew D. Economou, Paul M. W. French, James McGinty, Caroline S. Hill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c3a7ce8f93434e77b3526dc4eb45c12f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c3a7ce8f93434e77b3526dc4eb45c12f
record_format	dspace
spelling	oai:doaj.org-article:c3a7ce8f93434e77b3526dc4eb45c12f2021-11-08T11:10:58ZSmad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways10.1038/s41467-021-26486-32041-1723https://doaj.org/article/c3a7ce8f93434e77b3526dc4eb45c12f2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26486-3https://doaj.org/toc/2041-1723The role of the transcriptional effector SMAD4 in vertebrate embryo development remains unresolved. Here the authors show that in the absence of Smad4, dorsal/ventral embryo patterning is disrupted due to the loss of BMP signaling, while Nodal signaling is maintained, but insufficient for optimal endoderm specification.Luca GuglielmiClaire HeliotSunil KumarYuriy AlexandrovIlaria GoriFoteini PapaleonidopoulouChristopher BarringtonPhilip EastAndrew D. EconomouPaul M. W. FrenchJames McGintyCaroline S. HillNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luca Guglielmi Claire Heliot Sunil Kumar Yuriy Alexandrov Ilaria Gori Foteini Papaleonidopoulou Christopher Barrington Philip East Andrew D. Economou Paul M. W. French James McGinty Caroline S. Hill Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways
description	The role of the transcriptional effector SMAD4 in vertebrate embryo development remains unresolved. Here the authors show that in the absence of Smad4, dorsal/ventral embryo patterning is disrupted due to the loss of BMP signaling, while Nodal signaling is maintained, but insufficient for optimal endoderm specification.
format	article
author	Luca Guglielmi Claire Heliot Sunil Kumar Yuriy Alexandrov Ilaria Gori Foteini Papaleonidopoulou Christopher Barrington Philip East Andrew D. Economou Paul M. W. French James McGinty Caroline S. Hill
author_facet	Luca Guglielmi Claire Heliot Sunil Kumar Yuriy Alexandrov Ilaria Gori Foteini Papaleonidopoulou Christopher Barrington Philip East Andrew D. Economou Paul M. W. French James McGinty Caroline S. Hill
author_sort	Luca Guglielmi
title	Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways
title_short	Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways
title_full	Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways
title_fullStr	Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways
title_full_unstemmed	Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways
title_sort	smad4 controls signaling robustness and morphogenesis by differentially contributing to the nodal and bmp pathways
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c3a7ce8f93434e77b3526dc4eb45c12f
work_keys_str_mv	AT lucaguglielmi smad4controlssignalingrobustnessandmorphogenesisbydifferentiallycontributingtothenodalandbmppathways AT claireheliot smad4controlssignalingrobustnessandmorphogenesisbydifferentiallycontributingtothenodalandbmppathways AT sunilkumar smad4controlssignalingrobustnessandmorphogenesisbydifferentiallycontributingtothenodalandbmppathways AT yuriyalexandrov smad4controlssignalingrobustnessandmorphogenesisbydifferentiallycontributingtothenodalandbmppathways AT ilariagori smad4controlssignalingrobustnessandmorphogenesisbydifferentiallycontributingtothenodalandbmppathways AT foteinipapaleonidopoulou smad4controlssignalingrobustnessandmorphogenesisbydifferentiallycontributingtothenodalandbmppathways AT christopherbarrington smad4controlssignalingrobustnessandmorphogenesisbydifferentiallycontributingtothenodalandbmppathways AT philipeast smad4controlssignalingrobustnessandmorphogenesisbydifferentiallycontributingtothenodalandbmppathways AT andrewdeconomou smad4controlssignalingrobustnessandmorphogenesisbydifferentiallycontributingtothenodalandbmppathways AT paulmwfrench smad4controlssignalingrobustnessandmorphogenesisbydifferentiallycontributingtothenodalandbmppathways AT jamesmcginty smad4controlssignalingrobustnessandmorphogenesisbydifferentiallycontributingtothenodalandbmppathways AT carolineshill smad4controlssignalingrobustnessandmorphogenesisbydifferentiallycontributingtothenodalandbmppathways
_version_	1718442372152426496

Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways

Ejemplares similares