Dynamic physiological responses in obese and non-obese adults submitted to cardiopulmonary exercise test.

<h4>Purpose</h4>Obese individuals have reduced performance in cardiopulmonary exercise testing (CPET), mainly considering peak values of variables such as oxygen uptake ([Formula: see text]), carbon dioxide production ([Formula: see text]), tidal volume (Vt), minute ventilation ([Formula...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bárbara de Barros Gonze, Thatiane Lopes Valentim Di Paschoale Ostolin, Alan Carlos Brisola Barbosa, Agatha Caveda Matheus, Evandro Fornias Sperandio, Antônio Ricardo de Toledo Gagliardi, Rodolfo Leite Arantes, Marcello Romiti, Victor Zuniga Dourado
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c3a871dcb69a48dc81d3666d09879e5a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c3a871dcb69a48dc81d3666d09879e5a
record_format	dspace
spelling	oai:doaj.org-article:c3a871dcb69a48dc81d3666d09879e5a2021-12-02T20:19:38ZDynamic physiological responses in obese and non-obese adults submitted to cardiopulmonary exercise test.1932-620310.1371/journal.pone.0255724https://doaj.org/article/c3a871dcb69a48dc81d3666d09879e5a2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255724https://doaj.org/toc/1932-6203<h4>Purpose</h4>Obese individuals have reduced performance in cardiopulmonary exercise testing (CPET), mainly considering peak values of variables such as oxygen uptake ([Formula: see text]), carbon dioxide production ([Formula: see text]), tidal volume (Vt), minute ventilation ([Formula: see text]) and heart rate (HR). The CPET interpretation and prognostic value can be improved through submaximal ratios analysis of key variables like [Formula: see text], [Formula: see text], [Formula: see text] [Formula: see text] and oxygen uptake efficiency slope (OUES). The obesity influence on these responses has not yet been investigated. Our purpose was to evaluate the influence of adulthood obesity on maximal and submaximal physiological responses during CPET, emphasizing the analysis of submaximal dynamic variables.<h4>Methods</h4>We analyzed 1,594 CPETs of adults (755 obese participants, Body Mass Index ≥ 30 kg/m2) and compared the obtained variables among non-obese (normal weight and overweight) and obese groups (obesity classes I, II and III) through multivariate covariance analyses.<h4>Result</h4>Obesity influenced the majority of evaluated maximal and submaximal responses with worsened CPET performance. Cardiovascular, metabolic and gas exchange variables were the most influenced by obesity. Other maximal and submaximal responses were altered only in morbidly obese. Only a few cardiovascular and ventilatory variables presented inconsistent results. Additionally, Vtmax, [Formula: see text], Vt/Inspiratory Capacity, Vt/Forced Vital Capacity, Lowest [Formula: see text], [Formula: see text], and the y-intercepts of [Formula: see text] did not significantly differ regardless of obesity.<h4>Conclusion</h4>Obesity expressively influences the majority of CPET variables. However, the prognostic values of the main ventilatory efficiency responses remain unchanged. These dynamic responses are not dependent on maximum effort and may be useful in detecting incipient ventilatory disorder. Our results present great practical applicability in identifying exercise limitation, regardless of overweight and obesity.Bárbara de Barros GonzeThatiane Lopes Valentim Di Paschoale OstolinAlan Carlos Brisola BarbosaAgatha Caveda MatheusEvandro Fornias SperandioAntônio Ricardo de Toledo GagliardiRodolfo Leite ArantesMarcello RomitiVictor Zuniga DouradoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255724 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bárbara de Barros Gonze Thatiane Lopes Valentim Di Paschoale Ostolin Alan Carlos Brisola Barbosa Agatha Caveda Matheus Evandro Fornias Sperandio Antônio Ricardo de Toledo Gagliardi Rodolfo Leite Arantes Marcello Romiti Victor Zuniga Dourado Dynamic physiological responses in obese and non-obese adults submitted to cardiopulmonary exercise test.
description	<h4>Purpose</h4>Obese individuals have reduced performance in cardiopulmonary exercise testing (CPET), mainly considering peak values of variables such as oxygen uptake ([Formula: see text]), carbon dioxide production ([Formula: see text]), tidal volume (Vt), minute ventilation ([Formula: see text]) and heart rate (HR). The CPET interpretation and prognostic value can be improved through submaximal ratios analysis of key variables like [Formula: see text], [Formula: see text], [Formula: see text] [Formula: see text] and oxygen uptake efficiency slope (OUES). The obesity influence on these responses has not yet been investigated. Our purpose was to evaluate the influence of adulthood obesity on maximal and submaximal physiological responses during CPET, emphasizing the analysis of submaximal dynamic variables.<h4>Methods</h4>We analyzed 1,594 CPETs of adults (755 obese participants, Body Mass Index ≥ 30 kg/m2) and compared the obtained variables among non-obese (normal weight and overweight) and obese groups (obesity classes I, II and III) through multivariate covariance analyses.<h4>Result</h4>Obesity influenced the majority of evaluated maximal and submaximal responses with worsened CPET performance. Cardiovascular, metabolic and gas exchange variables were the most influenced by obesity. Other maximal and submaximal responses were altered only in morbidly obese. Only a few cardiovascular and ventilatory variables presented inconsistent results. Additionally, Vtmax, [Formula: see text], Vt/Inspiratory Capacity, Vt/Forced Vital Capacity, Lowest [Formula: see text], [Formula: see text], and the y-intercepts of [Formula: see text] did not significantly differ regardless of obesity.<h4>Conclusion</h4>Obesity expressively influences the majority of CPET variables. However, the prognostic values of the main ventilatory efficiency responses remain unchanged. These dynamic responses are not dependent on maximum effort and may be useful in detecting incipient ventilatory disorder. Our results present great practical applicability in identifying exercise limitation, regardless of overweight and obesity.
format	article
author	Bárbara de Barros Gonze Thatiane Lopes Valentim Di Paschoale Ostolin Alan Carlos Brisola Barbosa Agatha Caveda Matheus Evandro Fornias Sperandio Antônio Ricardo de Toledo Gagliardi Rodolfo Leite Arantes Marcello Romiti Victor Zuniga Dourado
author_facet	Bárbara de Barros Gonze Thatiane Lopes Valentim Di Paschoale Ostolin Alan Carlos Brisola Barbosa Agatha Caveda Matheus Evandro Fornias Sperandio Antônio Ricardo de Toledo Gagliardi Rodolfo Leite Arantes Marcello Romiti Victor Zuniga Dourado
author_sort	Bárbara de Barros Gonze
title	Dynamic physiological responses in obese and non-obese adults submitted to cardiopulmonary exercise test.
title_short	Dynamic physiological responses in obese and non-obese adults submitted to cardiopulmonary exercise test.
title_full	Dynamic physiological responses in obese and non-obese adults submitted to cardiopulmonary exercise test.
title_fullStr	Dynamic physiological responses in obese and non-obese adults submitted to cardiopulmonary exercise test.
title_full_unstemmed	Dynamic physiological responses in obese and non-obese adults submitted to cardiopulmonary exercise test.
title_sort	dynamic physiological responses in obese and non-obese adults submitted to cardiopulmonary exercise test.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c3a871dcb69a48dc81d3666d09879e5a
work_keys_str_mv	AT barbaradebarrosgonze dynamicphysiologicalresponsesinobeseandnonobeseadultssubmittedtocardiopulmonaryexercisetest AT thatianelopesvalentimdipaschoaleostolin dynamicphysiologicalresponsesinobeseandnonobeseadultssubmittedtocardiopulmonaryexercisetest AT alancarlosbrisolabarbosa dynamicphysiologicalresponsesinobeseandnonobeseadultssubmittedtocardiopulmonaryexercisetest AT agathacavedamatheus dynamicphysiologicalresponsesinobeseandnonobeseadultssubmittedtocardiopulmonaryexercisetest AT evandroforniassperandio dynamicphysiologicalresponsesinobeseandnonobeseadultssubmittedtocardiopulmonaryexercisetest AT antonioricardodetoledogagliardi dynamicphysiologicalresponsesinobeseandnonobeseadultssubmittedtocardiopulmonaryexercisetest AT rodolfoleitearantes dynamicphysiologicalresponsesinobeseandnonobeseadultssubmittedtocardiopulmonaryexercisetest AT marcelloromiti dynamicphysiologicalresponsesinobeseandnonobeseadultssubmittedtocardiopulmonaryexercisetest AT victorzunigadourado dynamicphysiologicalresponsesinobeseandnonobeseadultssubmittedtocardiopulmonaryexercisetest
_version_	1718374189560233984

Dynamic physiological responses in obese and non-obese adults submitted to cardiopulmonary exercise test.

Ejemplares similares