An integrated host-microbiome response to atrazine exposure mediates toxicity in Drosophila

An integrated host-microbiome response to atrazine exposure mediates toxicity in Drosophila

Brown et al. apply integrated omics and phenotypic screening to assess the role of the gut microbiome in modulating host resilience in Drosophila melanogaster. They find that Acetobacter tropicalis in gnotobiotic animals, is sufficient to rescue increased atrazine toxicity, which could pave the way...

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Autores principales: James B. Brown, Sasha A. Langley, Antoine M. Snijders, Kenneth H. Wan, Siti Nur Sarah Morris, Benjamin W. Booth, William W. Fisher, Ann S. Hammonds, Soo Park, Richard Weiszmann, Charles Yu, Jennifer A. Kirwan, Ralf J. M. Weber, Mark R. Viant, Jian-Hua Mao, Susan E. Celniker
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/c3ab3d12ed36490693a2a628de744736
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spelling oai:doaj.org-article:c3ab3d12ed36490693a2a628de7447362021-11-28T12:10:16ZAn integrated host-microbiome response to atrazine exposure mediates toxicity in Drosophila10.1038/s42003-021-02847-y2399-3642https://doaj.org/article/c3ab3d12ed36490693a2a628de7447362021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02847-yhttps://doaj.org/toc/2399-3642Brown et al. apply integrated omics and phenotypic screening to assess the role of the gut microbiome in modulating host resilience in Drosophila melanogaster. They find that Acetobacter tropicalis in gnotobiotic animals, is sufficient to rescue increased atrazine toxicity, which could pave the way for biotic strategies to improve host resilience to environmental chemical exposure.James B. BrownSasha A. LangleyAntoine M. SnijdersKenneth H. WanSiti Nur Sarah MorrisBenjamin W. BoothWilliam W. FisherAnn S. HammondsSoo ParkRichard WeiszmannCharles YuJennifer A. KirwanRalf J. M. WeberMark R. ViantJian-Hua MaoSusan E. CelnikerNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
James B. Brown
Sasha A. Langley
Antoine M. Snijders
Kenneth H. Wan
Siti Nur Sarah Morris
Benjamin W. Booth
William W. Fisher
Ann S. Hammonds
Soo Park
Richard Weiszmann
Charles Yu
Jennifer A. Kirwan
Ralf J. M. Weber
Mark R. Viant
Jian-Hua Mao
Susan E. Celniker
An integrated host-microbiome response to atrazine exposure mediates toxicity in Drosophila
description Brown et al. apply integrated omics and phenotypic screening to assess the role of the gut microbiome in modulating host resilience in Drosophila melanogaster. They find that Acetobacter tropicalis in gnotobiotic animals, is sufficient to rescue increased atrazine toxicity, which could pave the way for biotic strategies to improve host resilience to environmental chemical exposure.
format article
author James B. Brown
Sasha A. Langley
Antoine M. Snijders
Kenneth H. Wan
Siti Nur Sarah Morris
Benjamin W. Booth
William W. Fisher
Ann S. Hammonds
Soo Park
Richard Weiszmann
Charles Yu
Jennifer A. Kirwan
Ralf J. M. Weber
Mark R. Viant
Jian-Hua Mao
Susan E. Celniker
author_facet James B. Brown
Sasha A. Langley
Antoine M. Snijders
Kenneth H. Wan
Siti Nur Sarah Morris
Benjamin W. Booth
William W. Fisher
Ann S. Hammonds
Soo Park
Richard Weiszmann
Charles Yu
Jennifer A. Kirwan
Ralf J. M. Weber
Mark R. Viant
Jian-Hua Mao
Susan E. Celniker
author_sort James B. Brown
title An integrated host-microbiome response to atrazine exposure mediates toxicity in Drosophila
title_short An integrated host-microbiome response to atrazine exposure mediates toxicity in Drosophila
title_full An integrated host-microbiome response to atrazine exposure mediates toxicity in Drosophila
title_fullStr An integrated host-microbiome response to atrazine exposure mediates toxicity in Drosophila
title_full_unstemmed An integrated host-microbiome response to atrazine exposure mediates toxicity in Drosophila
title_sort integrated host-microbiome response to atrazine exposure mediates toxicity in drosophila
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c3ab3d12ed36490693a2a628de744736
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