p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response

Mutations in the gene encoding iRHOM2 are associated with hyperproliferative epidermal disorders. Here, the authors show that iRHOM2 is a target gene of p63, that together they regulate inflammation, cell survival and response to oxidative stress, and inhibition of p63-iRHOM2 signalling with an anti...

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Autores principales:	Paola Arcidiacono, Catherine M. Webb, Matthew A. Brooke, Huiqing Zhou, Paul J. Delaney, Keat-Eng Ng, Diana C. Blaydon, Andrew Tinker, David P. Kelsell, Anissa Chikh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c3aea6eca2d04247a2f4d1f9bed1b658
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spelling	oai:doaj.org-article:c3aea6eca2d04247a2f4d1f9bed1b6582021-12-02T14:39:22Zp63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response10.1038/s41467-018-03470-y2041-1723https://doaj.org/article/c3aea6eca2d04247a2f4d1f9bed1b6582018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03470-yhttps://doaj.org/toc/2041-1723Mutations in the gene encoding iRHOM2 are associated with hyperproliferative epidermal disorders. Here, the authors show that iRHOM2 is a target gene of p63, that together they regulate inflammation, cell survival and response to oxidative stress, and inhibition of p63-iRHOM2 signalling with an antioxidant reduces epidermal inflammation.Paola ArcidiaconoCatherine M. WebbMatthew A. BrookeHuiqing ZhouPaul J. DelaneyKeat-Eng NgDiana C. BlaydonAndrew TinkerDavid P. KelsellAnissa ChikhNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paola Arcidiacono Catherine M. Webb Matthew A. Brooke Huiqing Zhou Paul J. Delaney Keat-Eng Ng Diana C. Blaydon Andrew Tinker David P. Kelsell Anissa Chikh p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response
description	Mutations in the gene encoding iRHOM2 are associated with hyperproliferative epidermal disorders. Here, the authors show that iRHOM2 is a target gene of p63, that together they regulate inflammation, cell survival and response to oxidative stress, and inhibition of p63-iRHOM2 signalling with an antioxidant reduces epidermal inflammation.
format	article
author	Paola Arcidiacono Catherine M. Webb Matthew A. Brooke Huiqing Zhou Paul J. Delaney Keat-Eng Ng Diana C. Blaydon Andrew Tinker David P. Kelsell Anissa Chikh
author_facet	Paola Arcidiacono Catherine M. Webb Matthew A. Brooke Huiqing Zhou Paul J. Delaney Keat-Eng Ng Diana C. Blaydon Andrew Tinker David P. Kelsell Anissa Chikh
author_sort	Paola Arcidiacono
title	p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response
title_short	p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response
title_full	p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response
title_fullStr	p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response
title_full_unstemmed	p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response
title_sort	p63 is a key regulator of irhom2 signalling in the keratinocyte stress response
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c3aea6eca2d04247a2f4d1f9bed1b658
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p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response

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