TALPID3 and ANKRD26 selectively orchestrate FBF1 localization and cilia gating

Most cells possess sensory cilia, which need to be gated properly. Here the authors show that the C. elegans proteins TALP-3 and ANKR-26 coordinate cilia gating in the context of transition fibers and that this mechanism is conserved in mammalian cells and likely implicated in certain ciliopathies.

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Detalles Bibliográficos
Autores principales: Hao Yan, Chuan Chen, Huicheng Chen, Hui Hong, Yan Huang, Kun Ling, Jinghua Hu, Qing Wei
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/c3aefe43facd4d7a9b3f9eb42275c192
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Sumario:Most cells possess sensory cilia, which need to be gated properly. Here the authors show that the C. elegans proteins TALP-3 and ANKR-26 coordinate cilia gating in the context of transition fibers and that this mechanism is conserved in mammalian cells and likely implicated in certain ciliopathies.