Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression

Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression

Chromatin structure plays a significant role in the regulation of gene expression. Here the authors show that TFIIH interacts with the histone acetyl transferase KAT2A and recruits the ATAC/hSAGA complexes to chromatin; and that loss of xeroderma pigmentosum group B (XPB) function results in chromat...

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Main Authors: Jérémy Sandoz, Zita Nagy, Philippe Catez, Gizem Caliskan, Sylvain Geny, Jean-Baptiste Renaud, Jean-Paul Concordet, Arnaud Poterszman, Laszlo Tora, Jean-Marc Egly, Nicolas Le May, Frédéric Coin
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/c3b2c0ec8f5b4543bcc98340f8ba7994
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Summary:Chromatin structure plays a significant role in the regulation of gene expression. Here the authors show that TFIIH interacts with the histone acetyl transferase KAT2A and recruits the ATAC/hSAGA complexes to chromatin; and that loss of xeroderma pigmentosum group B (XPB) function results in chromatin decondensation and increased gene expression through activation of KAT2A.

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