Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression

Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression

Chromatin structure plays a significant role in the regulation of gene expression. Here the authors show that TFIIH interacts with the histone acetyl transferase KAT2A and recruits the ATAC/hSAGA complexes to chromatin; and that loss of xeroderma pigmentosum group B (XPB) function results in chromat...

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Autores principales: Jérémy Sandoz, Zita Nagy, Philippe Catez, Gizem Caliskan, Sylvain Geny, Jean-Baptiste Renaud, Jean-Paul Concordet, Arnaud Poterszman, Laszlo Tora, Jean-Marc Egly, Nicolas Le May, Frédéric Coin
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/c3b2c0ec8f5b4543bcc98340f8ba7994
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spelling oai:doaj.org-article:c3b2c0ec8f5b4543bcc98340f8ba79942021-12-02T17:02:15ZFunctional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression10.1038/s41467-019-09270-22041-1723https://doaj.org/article/c3b2c0ec8f5b4543bcc98340f8ba79942019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09270-2https://doaj.org/toc/2041-1723Chromatin structure plays a significant role in the regulation of gene expression. Here the authors show that TFIIH interacts with the histone acetyl transferase KAT2A and recruits the ATAC/hSAGA complexes to chromatin; and that loss of xeroderma pigmentosum group B (XPB) function results in chromatin decondensation and increased gene expression through activation of KAT2A.Jérémy SandozZita NagyPhilippe CatezGizem CaliskanSylvain GenyJean-Baptiste RenaudJean-Paul ConcordetArnaud PoterszmanLaszlo ToraJean-Marc EglyNicolas Le MayFrédéric CoinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jérémy Sandoz
Zita Nagy
Philippe Catez
Gizem Caliskan
Sylvain Geny
Jean-Baptiste Renaud
Jean-Paul Concordet
Arnaud Poterszman
Laszlo Tora
Jean-Marc Egly
Nicolas Le May
Frédéric Coin
Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression
description Chromatin structure plays a significant role in the regulation of gene expression. Here the authors show that TFIIH interacts with the histone acetyl transferase KAT2A and recruits the ATAC/hSAGA complexes to chromatin; and that loss of xeroderma pigmentosum group B (XPB) function results in chromatin decondensation and increased gene expression through activation of KAT2A.
format article
author Jérémy Sandoz
Zita Nagy
Philippe Catez
Gizem Caliskan
Sylvain Geny
Jean-Baptiste Renaud
Jean-Paul Concordet
Arnaud Poterszman
Laszlo Tora
Jean-Marc Egly
Nicolas Le May
Frédéric Coin
author_facet Jérémy Sandoz
Zita Nagy
Philippe Catez
Gizem Caliskan
Sylvain Geny
Jean-Baptiste Renaud
Jean-Paul Concordet
Arnaud Poterszman
Laszlo Tora
Jean-Marc Egly
Nicolas Le May
Frédéric Coin
author_sort Jérémy Sandoz
title Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression
title_short Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression
title_full Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression
title_fullStr Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression
title_full_unstemmed Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression
title_sort functional interplay between tfiih and kat2a regulates higher-order chromatin structure and class ii gene expression
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/c3b2c0ec8f5b4543bcc98340f8ba7994
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