A multiscale model of early cell lineage specification including cell division

Author summary The early development of the mammalian embryo involves cell divisions and highly regulated lineage specification events. Cell fates are determined by gene regulatory networks exhibiting multiple steady states. The question arises as to how these networks interact with extracellular si...

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Autores principales:	Alen Tosenberger, Didier Gonze, Sylvain Bessonnard, Michel Cohen-Tannoudji, Claire Chazaud, Geneviève Dupont
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c3b7a869a7df450abdde89f8ddc5a847
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spelling	oai:doaj.org-article:c3b7a869a7df450abdde89f8ddc5a8472021-12-02T11:41:51ZA multiscale model of early cell lineage specification including cell division10.1038/s41540-017-0017-02056-7189https://doaj.org/article/c3b7a869a7df450abdde89f8ddc5a8472017-06-01T00:00:00Zhttps://doi.org/10.1038/s41540-017-0017-0https://doaj.org/toc/2056-7189Author summary The early development of the mammalian embryo involves cell divisions and highly regulated lineage specification events. Cell fates are determined by gene regulatory networks exhibiting multiple steady states. The question arises as to how these networks interact with extracellular signalling, cell division and cell movement. Here, we investigate this question in the context of establishment of the salt-and-pepper pattern of epiblast (Epi) and primitive endoderm (PrE) cells within the inner cell mass (ICM) of the preimplantation embryo in the mouse, using a multi-scale computational model. The three cell fates correspond to three stable steady states of the gene regulatory network, which coexist in the salt-and-pepper pattern. The specification process is self-regulated through extracellular signalling and is robust towards cell division and cell movement.Alen TosenbergerDidier GonzeSylvain BessonnardMichel Cohen-TannoudjiClaire ChazaudGeneviève DupontNature PortfolioarticleBiology (General)QH301-705.5ENnpj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Alen Tosenberger Didier Gonze Sylvain Bessonnard Michel Cohen-Tannoudji Claire Chazaud Geneviève Dupont A multiscale model of early cell lineage specification including cell division
description	Author summary The early development of the mammalian embryo involves cell divisions and highly regulated lineage specification events. Cell fates are determined by gene regulatory networks exhibiting multiple steady states. The question arises as to how these networks interact with extracellular signalling, cell division and cell movement. Here, we investigate this question in the context of establishment of the salt-and-pepper pattern of epiblast (Epi) and primitive endoderm (PrE) cells within the inner cell mass (ICM) of the preimplantation embryo in the mouse, using a multi-scale computational model. The three cell fates correspond to three stable steady states of the gene regulatory network, which coexist in the salt-and-pepper pattern. The specification process is self-regulated through extracellular signalling and is robust towards cell division and cell movement.
format	article
author	Alen Tosenberger Didier Gonze Sylvain Bessonnard Michel Cohen-Tannoudji Claire Chazaud Geneviève Dupont
author_facet	Alen Tosenberger Didier Gonze Sylvain Bessonnard Michel Cohen-Tannoudji Claire Chazaud Geneviève Dupont
author_sort	Alen Tosenberger
title	A multiscale model of early cell lineage specification including cell division
title_short	A multiscale model of early cell lineage specification including cell division
title_full	A multiscale model of early cell lineage specification including cell division
title_fullStr	A multiscale model of early cell lineage specification including cell division
title_full_unstemmed	A multiscale model of early cell lineage specification including cell division
title_sort	multiscale model of early cell lineage specification including cell division
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c3b7a869a7df450abdde89f8ddc5a847
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A multiscale model of early cell lineage specification including cell division

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