Longitudinal changes in complete avascular area assessed using anterior segmental optical coherence tomography angiography in filtering trabeculectomy bleb

Abstract Optical coherence tomography angiography (OCTA) is a new technique for non-invasive imaging of blood vessels, allowing combined evaluation of both deep and surface vessels. The purpose of this study was to evaluate the post-trabeculectomy longitudinal changes in complete avascular area (CAA...

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Autores principales:	Ai Kido, Tadamichi Akagi, Hanako Ohashi Ikeda, Takanori Kameda, Kenji Suda, Masahiro Miyake, Tomoko Hasegawa, Shogo Numa, Akitaka Tsujikawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c3ba4cc9cd49457fbf363b618f8288b2
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spelling	oai:doaj.org-article:c3ba4cc9cd49457fbf363b618f8288b22021-12-05T12:15:05ZLongitudinal changes in complete avascular area assessed using anterior segmental optical coherence tomography angiography in filtering trabeculectomy bleb10.1038/s41598-021-02871-22045-2322https://doaj.org/article/c3ba4cc9cd49457fbf363b618f8288b22021-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02871-2https://doaj.org/toc/2045-2322Abstract Optical coherence tomography angiography (OCTA) is a new technique for non-invasive imaging of blood vessels, allowing combined evaluation of both deep and surface vessels. The purpose of this study was to evaluate the post-trabeculectomy longitudinal changes in complete avascular area (CAA) of filtering blebs using anterior segment (AS-) OCTA and their association with surgical outcomes. This study included 57 eyes of 53 patients who had undergone trabeculectomy with mitomycin C. AS-OCTA images of filtering bleb were acquired at 3 and 6 months after trabeculectomy, and at 1 month in possible cases. CAAs, regions where complete blood flow was not depicted in AS-OCTA images, were evaluated for their presence, extent, and change over time. CAAs were detected in 37 eyes (65%) and 33 eyes (58%) at 3 and 6 months postoperatively, respectively. The extent of CAAs reduced over time after surgery in most cases. No parameters related to CAAs were significantly associated with surgical success (i.e., intraocular pressure (IOP) ≤ 12 mmHg and IOP reduction > 20% without medication). In conclusion, although it is difficult to predict surgical success by CAA itself, AS-OCTA may be useful for the objective evaluation of the vascularity of filtering blebs.Ai KidoTadamichi AkagiHanako Ohashi IkedaTakanori KamedaKenji SudaMasahiro MiyakeTomoko HasegawaShogo NumaAkitaka TsujikawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ai Kido Tadamichi Akagi Hanako Ohashi Ikeda Takanori Kameda Kenji Suda Masahiro Miyake Tomoko Hasegawa Shogo Numa Akitaka Tsujikawa Longitudinal changes in complete avascular area assessed using anterior segmental optical coherence tomography angiography in filtering trabeculectomy bleb
description	Abstract Optical coherence tomography angiography (OCTA) is a new technique for non-invasive imaging of blood vessels, allowing combined evaluation of both deep and surface vessels. The purpose of this study was to evaluate the post-trabeculectomy longitudinal changes in complete avascular area (CAA) of filtering blebs using anterior segment (AS-) OCTA and their association with surgical outcomes. This study included 57 eyes of 53 patients who had undergone trabeculectomy with mitomycin C. AS-OCTA images of filtering bleb were acquired at 3 and 6 months after trabeculectomy, and at 1 month in possible cases. CAAs, regions where complete blood flow was not depicted in AS-OCTA images, were evaluated for their presence, extent, and change over time. CAAs were detected in 37 eyes (65%) and 33 eyes (58%) at 3 and 6 months postoperatively, respectively. The extent of CAAs reduced over time after surgery in most cases. No parameters related to CAAs were significantly associated with surgical success (i.e., intraocular pressure (IOP) ≤ 12 mmHg and IOP reduction > 20% without medication). In conclusion, although it is difficult to predict surgical success by CAA itself, AS-OCTA may be useful for the objective evaluation of the vascularity of filtering blebs.
format	article
author	Ai Kido Tadamichi Akagi Hanako Ohashi Ikeda Takanori Kameda Kenji Suda Masahiro Miyake Tomoko Hasegawa Shogo Numa Akitaka Tsujikawa
author_facet	Ai Kido Tadamichi Akagi Hanako Ohashi Ikeda Takanori Kameda Kenji Suda Masahiro Miyake Tomoko Hasegawa Shogo Numa Akitaka Tsujikawa
author_sort	Ai Kido
title	Longitudinal changes in complete avascular area assessed using anterior segmental optical coherence tomography angiography in filtering trabeculectomy bleb
title_short	Longitudinal changes in complete avascular area assessed using anterior segmental optical coherence tomography angiography in filtering trabeculectomy bleb
title_full	Longitudinal changes in complete avascular area assessed using anterior segmental optical coherence tomography angiography in filtering trabeculectomy bleb
title_fullStr	Longitudinal changes in complete avascular area assessed using anterior segmental optical coherence tomography angiography in filtering trabeculectomy bleb
title_full_unstemmed	Longitudinal changes in complete avascular area assessed using anterior segmental optical coherence tomography angiography in filtering trabeculectomy bleb
title_sort	longitudinal changes in complete avascular area assessed using anterior segmental optical coherence tomography angiography in filtering trabeculectomy bleb
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c3ba4cc9cd49457fbf363b618f8288b2
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Longitudinal changes in complete avascular area assessed using anterior segmental optical coherence tomography angiography in filtering trabeculectomy bleb

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