Peptide Regulation of Gene Expression: A Systematic Review

Peptides are characterized by their wide range of biological activity: they regulate functions of the endocrine, nervous, and immune systems. The mechanism of such action of peptides involves their ability to regulate gene expression and protein synthesis in plants, microorganisms, insects, birds, r...

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Autores principales:	Vladimir Khatskelevich Khavinson, Irina Grigor’evna Popovich, Natalia Sergeevna Linkova, Ekaterina Sergeevna Mironova, Anastasiia Romanovna Ilina
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	short peptides DNA–peptide interactions histones epigenetics peptide drugs Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/c3be9ac2c60f4a04a445a9aa3b88317c
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spelling	oai:doaj.org-article:c3be9ac2c60f4a04a445a9aa3b88317c2021-11-25T18:29:29ZPeptide Regulation of Gene Expression: A Systematic Review10.3390/molecules262270531420-3049https://doaj.org/article/c3be9ac2c60f4a04a445a9aa3b88317c2021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/7053https://doaj.org/toc/1420-3049Peptides are characterized by their wide range of biological activity: they regulate functions of the endocrine, nervous, and immune systems. The mechanism of such action of peptides involves their ability to regulate gene expression and protein synthesis in plants, microorganisms, insects, birds, rodents, primates, and humans. Short peptides, consisting of 2–7 amino acid residues, can penetrate into the nuclei and nucleoli of cells and interact with the nucleosome, the histone proteins, and both single- and double-stranded DNA. DNA–peptide interactions, including sequence recognition in gene promoters, are important for template-directed synthetic reactions, replication, transcription, and reparation. Peptides can regulate the status of DNA methylation, which is an epigenetic mechanism for the activation or repression of genes in both the normal condition, as well as in cases of pathology and senescence. In this context, one can assume that short peptides were evolutionarily among the first signaling molecules that regulated the reactions of template-directed syntheses. This situation enhances the prospects of developing effective and safe immunoregulatory, neuroprotective, antimicrobial, antiviral, and other drugs based on short peptides.Vladimir Khatskelevich KhavinsonIrina Grigor’evna PopovichNatalia Sergeevna LinkovaEkaterina Sergeevna MironovaAnastasiia Romanovna IlinaMDPI AGarticleshort peptidesDNA–peptide interactionshistonesepigeneticspeptide drugsOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 7053, p 7053 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	short peptides DNA–peptide interactions histones epigenetics peptide drugs Organic chemistry QD241-441
spellingShingle	short peptides DNA–peptide interactions histones epigenetics peptide drugs Organic chemistry QD241-441 Vladimir Khatskelevich Khavinson Irina Grigor’evna Popovich Natalia Sergeevna Linkova Ekaterina Sergeevna Mironova Anastasiia Romanovna Ilina Peptide Regulation of Gene Expression: A Systematic Review
description	Peptides are characterized by their wide range of biological activity: they regulate functions of the endocrine, nervous, and immune systems. The mechanism of such action of peptides involves their ability to regulate gene expression and protein synthesis in plants, microorganisms, insects, birds, rodents, primates, and humans. Short peptides, consisting of 2–7 amino acid residues, can penetrate into the nuclei and nucleoli of cells and interact with the nucleosome, the histone proteins, and both single- and double-stranded DNA. DNA–peptide interactions, including sequence recognition in gene promoters, are important for template-directed synthetic reactions, replication, transcription, and reparation. Peptides can regulate the status of DNA methylation, which is an epigenetic mechanism for the activation or repression of genes in both the normal condition, as well as in cases of pathology and senescence. In this context, one can assume that short peptides were evolutionarily among the first signaling molecules that regulated the reactions of template-directed syntheses. This situation enhances the prospects of developing effective and safe immunoregulatory, neuroprotective, antimicrobial, antiviral, and other drugs based on short peptides.
format	article
author	Vladimir Khatskelevich Khavinson Irina Grigor’evna Popovich Natalia Sergeevna Linkova Ekaterina Sergeevna Mironova Anastasiia Romanovna Ilina
author_facet	Vladimir Khatskelevich Khavinson Irina Grigor’evna Popovich Natalia Sergeevna Linkova Ekaterina Sergeevna Mironova Anastasiia Romanovna Ilina
author_sort	Vladimir Khatskelevich Khavinson
title	Peptide Regulation of Gene Expression: A Systematic Review
title_short	Peptide Regulation of Gene Expression: A Systematic Review
title_full	Peptide Regulation of Gene Expression: A Systematic Review
title_fullStr	Peptide Regulation of Gene Expression: A Systematic Review
title_full_unstemmed	Peptide Regulation of Gene Expression: A Systematic Review
title_sort	peptide regulation of gene expression: a systematic review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c3be9ac2c60f4a04a445a9aa3b88317c
work_keys_str_mv	AT vladimirkhatskelevichkhavinson peptideregulationofgeneexpressionasystematicreview AT irinagrigorevnapopovich peptideregulationofgeneexpressionasystematicreview AT nataliasergeevnalinkova peptideregulationofgeneexpressionasystematicreview AT ekaterinasergeevnamironova peptideregulationofgeneexpressionasystematicreview AT anastasiiaromanovnailina peptideregulationofgeneexpressionasystematicreview
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Peptide Regulation of Gene Expression: A Systematic Review

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