Association of IGFBP3 Gene (rs2854744) Polymorphism and Colorectal Cancer

BACKGROUND AND OBJECTIVE: The bioavailability of IGF1 is regulated by the insulin-like growth factor binding protein 3 (IGFBP3). IGFBP3 is an inhibitor of IGF1 and inhibits growth cell and induces apoptosis by joining to it. Some studies have shown that reduction of IGFBP3 level cause to increase ri...

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Autores principales:	M Arkani, KH Karimi, A Safaei, M Vahedi, SR Mohebi, SR Fatemi, M Vafaei, MR Zali
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2012
Materias:	genetic polymorphism pcr–rflp insulin-like growth factor binding protein 3 colorectal neoplasms Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c3c70450cdaf49af99114daf3318d0ce
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spelling	oai:doaj.org-article:c3c70450cdaf49af99114daf3318d0ce2021-11-10T08:53:11ZAssociation of IGFBP3 Gene (rs2854744) Polymorphism and Colorectal Cancer1561-41072251-7170https://doaj.org/article/c3c70450cdaf49af99114daf3318d0ce2012-05-01T00:00:00Zhttp://jbums.org/article-1-4089-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: The bioavailability of IGF1 is regulated by the insulin-like growth factor binding protein 3 (IGFBP3). IGFBP3 is an inhibitor of IGF1 and inhibits growth cell and induces apoptosis by joining to it. Some studies have shown that reduction of IGFBP3 level cause to increase risk of colorectal cancer (CRC). The purpose of this study was to investigate incidence of mutant allele of IGFBP3 polymorphism rs2854744 in Iranian community and to examine the association of genetic variants in IGFBP3 (rs2854744) with risk of colorectal cancer.METHODS: In this case-control study, genotyping of IGFBP3 gene were determined in series of 120 colorectal cancer patients (with positive result for colonoscopy and pathology) and 120 controls (with negative result for colonoscopy and pathology ) by using polymerase chain reaction and restriction fragment length polymorphism genotyping assay (PCR-RFLP) and compared.FINDINGS: Frequency of CC, CA and AA genotype in patients in IGFBP32854744 was 33.3%, 47.5% and 19.2%, and frequency for controls was 34.2%, 45.8%, and 20%, respectively. Frequency of C allele in patients was 0.57% and for A allele was 0.42%. Also frequency of C allele in controls 0.57% and in A allele was 0.42% that no significant difference was seen. CONCLUSION: These findings suggest that polymorphism IGFBP3 rs 2854744, is not associated with increased risk of CRC.M ArkaniKH KarimiA SafaeiM VahediSR MohebiSR FatemiM VafaeiMR ZaliBabol University of Medical Sciencesarticlegenetic polymorphismpcr–rflpinsulin-like growth factor binding protein 3colorectal neoplasmsMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 14, Iss 3, Pp 46-51 (2012)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	genetic polymorphism pcr–rflp insulin-like growth factor binding protein 3 colorectal neoplasms Medicine R Medicine (General) R5-920
spellingShingle	genetic polymorphism pcr–rflp insulin-like growth factor binding protein 3 colorectal neoplasms Medicine R Medicine (General) R5-920 M Arkani KH Karimi A Safaei M Vahedi SR Mohebi SR Fatemi M Vafaei MR Zali Association of IGFBP3 Gene (rs2854744) Polymorphism and Colorectal Cancer
description	BACKGROUND AND OBJECTIVE: The bioavailability of IGF1 is regulated by the insulin-like growth factor binding protein 3 (IGFBP3). IGFBP3 is an inhibitor of IGF1 and inhibits growth cell and induces apoptosis by joining to it. Some studies have shown that reduction of IGFBP3 level cause to increase risk of colorectal cancer (CRC). The purpose of this study was to investigate incidence of mutant allele of IGFBP3 polymorphism rs2854744 in Iranian community and to examine the association of genetic variants in IGFBP3 (rs2854744) with risk of colorectal cancer.METHODS: In this case-control study, genotyping of IGFBP3 gene were determined in series of 120 colorectal cancer patients (with positive result for colonoscopy and pathology) and 120 controls (with negative result for colonoscopy and pathology ) by using polymerase chain reaction and restriction fragment length polymorphism genotyping assay (PCR-RFLP) and compared.FINDINGS: Frequency of CC, CA and AA genotype in patients in IGFBP32854744 was 33.3%, 47.5% and 19.2%, and frequency for controls was 34.2%, 45.8%, and 20%, respectively. Frequency of C allele in patients was 0.57% and for A allele was 0.42%. Also frequency of C allele in controls 0.57% and in A allele was 0.42% that no significant difference was seen. CONCLUSION: These findings suggest that polymorphism IGFBP3 rs 2854744, is not associated with increased risk of CRC.
format	article
author	M Arkani KH Karimi A Safaei M Vahedi SR Mohebi SR Fatemi M Vafaei MR Zali
author_facet	M Arkani KH Karimi A Safaei M Vahedi SR Mohebi SR Fatemi M Vafaei MR Zali
author_sort	M Arkani
title	Association of IGFBP3 Gene (rs2854744) Polymorphism and Colorectal Cancer
title_short	Association of IGFBP3 Gene (rs2854744) Polymorphism and Colorectal Cancer
title_full	Association of IGFBP3 Gene (rs2854744) Polymorphism and Colorectal Cancer
title_fullStr	Association of IGFBP3 Gene (rs2854744) Polymorphism and Colorectal Cancer
title_full_unstemmed	Association of IGFBP3 Gene (rs2854744) Polymorphism and Colorectal Cancer
title_sort	association of igfbp3 gene (rs2854744) polymorphism and colorectal cancer
publisher	Babol University of Medical Sciences
publishDate	2012
url	https://doaj.org/article/c3c70450cdaf49af99114daf3318d0ce
work_keys_str_mv	AT markani associationofigfbp3geners2854744polymorphismandcolorectalcancer AT khkarimi associationofigfbp3geners2854744polymorphismandcolorectalcancer AT asafaei associationofigfbp3geners2854744polymorphismandcolorectalcancer AT mvahedi associationofigfbp3geners2854744polymorphismandcolorectalcancer AT srmohebi associationofigfbp3geners2854744polymorphismandcolorectalcancer AT srfatemi associationofigfbp3geners2854744polymorphismandcolorectalcancer AT mvafaei associationofigfbp3geners2854744polymorphismandcolorectalcancer AT mrzali associationofigfbp3geners2854744polymorphismandcolorectalcancer
_version_	1718440416102055936

Association of IGFBP3 Gene (rs2854744) Polymorphism and Colorectal Cancer

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