Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish

Following spinal injury in zebrafish, non-neural cells establish an extracellular matrix to promote axon re-growth but how this is regulated is unclear. Here, the authors show that Wnt/β-catenin signaling in fibroblast-like cells at a lesion activates axon re-growth via deposition of Collagen XII.

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Autores principales:	Daniel Wehner, Themistoklis M. Tsarouchas, Andria Michael, Christa Haase, Gilbert Weidinger, Michell M. Reimer, Thomas Becker, Catherina G. Becker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c3ca8d8280e24c85b351e0dcdd875413
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spelling	oai:doaj.org-article:c3ca8d8280e24c85b351e0dcdd8754132021-12-02T13:27:30ZWnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish10.1038/s41467-017-00143-02041-1723https://doaj.org/article/c3ca8d8280e24c85b351e0dcdd8754132017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00143-0https://doaj.org/toc/2041-1723Following spinal injury in zebrafish, non-neural cells establish an extracellular matrix to promote axon re-growth but how this is regulated is unclear. Here, the authors show that Wnt/β-catenin signaling in fibroblast-like cells at a lesion activates axon re-growth via deposition of Collagen XII.Daniel WehnerThemistoklis M. TsarouchasAndria MichaelChrista HaaseGilbert WeidingerMichell M. ReimerThomas BeckerCatherina G. BeckerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Wehner Themistoklis M. Tsarouchas Andria Michael Christa Haase Gilbert Weidinger Michell M. Reimer Thomas Becker Catherina G. Becker Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish
description	Following spinal injury in zebrafish, non-neural cells establish an extracellular matrix to promote axon re-growth but how this is regulated is unclear. Here, the authors show that Wnt/β-catenin signaling in fibroblast-like cells at a lesion activates axon re-growth via deposition of Collagen XII.
format	article
author	Daniel Wehner Themistoklis M. Tsarouchas Andria Michael Christa Haase Gilbert Weidinger Michell M. Reimer Thomas Becker Catherina G. Becker
author_facet	Daniel Wehner Themistoklis M. Tsarouchas Andria Michael Christa Haase Gilbert Weidinger Michell M. Reimer Thomas Becker Catherina G. Becker
author_sort	Daniel Wehner
title	Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish
title_short	Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish
title_full	Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish
title_fullStr	Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish
title_full_unstemmed	Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish
title_sort	wnt signaling controls pro-regenerative collagen xii in functional spinal cord regeneration in zebrafish
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c3ca8d8280e24c85b351e0dcdd875413
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Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish

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