Alleviation of Osteoarthritis-Induced Pain and Motor Deficits in Rats by a Novel Device for the Intramuscular Insertion of Cog Polydioxanone Filament

The importance of skeletal muscles in the development of osteoarthritis (OA) is known. However, in OA, strengthening the muscle is arduous process. This study investigated the effects of muscle enhancement and support therapy (MEST), a novel device for the intramuscular insertion of cog polydioxanon...

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Autores principales:	Kilyong Lee, Geung Gyu Gang, Yun Gyu Kang, Sung Sam Jung, Hee-Gon Park, Jun Ho Jang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	osteoarthritis skeletal muscle pain motor impairment polydioxanone Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c3cd90d9f6f645098f4493504aeb714b
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spelling	oai:doaj.org-article:c3cd90d9f6f645098f4493504aeb714b2021-11-25T16:30:55ZAlleviation of Osteoarthritis-Induced Pain and Motor Deficits in Rats by a Novel Device for the Intramuscular Insertion of Cog Polydioxanone Filament10.3390/app1122105342076-3417https://doaj.org/article/c3cd90d9f6f645098f4493504aeb714b2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/10534https://doaj.org/toc/2076-3417The importance of skeletal muscles in the development of osteoarthritis (OA) is known. However, in OA, strengthening the muscle is arduous process. This study investigated the effects of muscle enhancement and support therapy (MEST), a novel device for the intramuscular insertion of cog polydioxanone filament intended to hold and stimulate surrounding muscles, on OA-induced symptoms. In our results, the MEST attenuated OA-induced pain and mobility limitations, as evidenced by increases in withdrawal thresholds, rearing duration and travelled distance in an open cage, and fall latency from rotarod. It further restored atrophic rectus femoris muscle (RFM) in OA animals by increasing mass, decreasing nucleus density, and increasing the cross-sectional area of muscle fibers. Decreased collagen and insulin-like growth factor 1 levels in OA animals were restored without affecting the interleukin-6 and tumor necrosis factor-alpha levels in RFM. No evidence of structural improvement in the knee was observed via computed tomography after MEST. These results suggest that MEST in the quadriceps is effective for relieving pain and motor impairment in knee OA animals by restoring atrophic muscles, providing a novel therapeutic strategy for OA symptom management.Kilyong LeeGeung Gyu GangYun Gyu KangSung Sam JungHee-Gon ParkJun Ho JangMDPI AGarticleosteoarthritisskeletal musclepainmotor impairmentpolydioxanoneTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10534, p 10534 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteoarthritis skeletal muscle pain motor impairment polydioxanone Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	osteoarthritis skeletal muscle pain motor impairment polydioxanone Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Kilyong Lee Geung Gyu Gang Yun Gyu Kang Sung Sam Jung Hee-Gon Park Jun Ho Jang Alleviation of Osteoarthritis-Induced Pain and Motor Deficits in Rats by a Novel Device for the Intramuscular Insertion of Cog Polydioxanone Filament
description	The importance of skeletal muscles in the development of osteoarthritis (OA) is known. However, in OA, strengthening the muscle is arduous process. This study investigated the effects of muscle enhancement and support therapy (MEST), a novel device for the intramuscular insertion of cog polydioxanone filament intended to hold and stimulate surrounding muscles, on OA-induced symptoms. In our results, the MEST attenuated OA-induced pain and mobility limitations, as evidenced by increases in withdrawal thresholds, rearing duration and travelled distance in an open cage, and fall latency from rotarod. It further restored atrophic rectus femoris muscle (RFM) in OA animals by increasing mass, decreasing nucleus density, and increasing the cross-sectional area of muscle fibers. Decreased collagen and insulin-like growth factor 1 levels in OA animals were restored without affecting the interleukin-6 and tumor necrosis factor-alpha levels in RFM. No evidence of structural improvement in the knee was observed via computed tomography after MEST. These results suggest that MEST in the quadriceps is effective for relieving pain and motor impairment in knee OA animals by restoring atrophic muscles, providing a novel therapeutic strategy for OA symptom management.
format	article
author	Kilyong Lee Geung Gyu Gang Yun Gyu Kang Sung Sam Jung Hee-Gon Park Jun Ho Jang
author_facet	Kilyong Lee Geung Gyu Gang Yun Gyu Kang Sung Sam Jung Hee-Gon Park Jun Ho Jang
author_sort	Kilyong Lee
title	Alleviation of Osteoarthritis-Induced Pain and Motor Deficits in Rats by a Novel Device for the Intramuscular Insertion of Cog Polydioxanone Filament
title_short	Alleviation of Osteoarthritis-Induced Pain and Motor Deficits in Rats by a Novel Device for the Intramuscular Insertion of Cog Polydioxanone Filament
title_full	Alleviation of Osteoarthritis-Induced Pain and Motor Deficits in Rats by a Novel Device for the Intramuscular Insertion of Cog Polydioxanone Filament
title_fullStr	Alleviation of Osteoarthritis-Induced Pain and Motor Deficits in Rats by a Novel Device for the Intramuscular Insertion of Cog Polydioxanone Filament
title_full_unstemmed	Alleviation of Osteoarthritis-Induced Pain and Motor Deficits in Rats by a Novel Device for the Intramuscular Insertion of Cog Polydioxanone Filament
title_sort	alleviation of osteoarthritis-induced pain and motor deficits in rats by a novel device for the intramuscular insertion of cog polydioxanone filament
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c3cd90d9f6f645098f4493504aeb714b
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Alleviation of Osteoarthritis-Induced Pain and Motor Deficits in Rats by a Novel Device for the Intramuscular Insertion of Cog Polydioxanone Filament

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