Cross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes

Cross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes

Synaptic vesicles store neurotransmitters and fuse with the pre-synaptic membrane when an action potential arrives at the nerve terminal. Here authors apply cross-linking mass spectrometry to study interactions of synaptic vesicle proteins and describe a protein network of vesicle sub-populations an...

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Autores principales: Sabine Wittig, Marcelo Ganzella, Marie Barth, Susann Kostmann, Dietmar Riedel, Ángel Pérez-Lara, Reinhard Jahn, Carla Schmidt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c3cf31e15d2448abbfa6da7820c787aa
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spelling oai:doaj.org-article:c3cf31e15d2448abbfa6da7820c787aa2021-12-02T14:26:51ZCross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes10.1038/s41467-021-21102-w2041-1723https://doaj.org/article/c3cf31e15d2448abbfa6da7820c787aa2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21102-whttps://doaj.org/toc/2041-1723Synaptic vesicles store neurotransmitters and fuse with the pre-synaptic membrane when an action potential arrives at the nerve terminal. Here authors apply cross-linking mass spectrometry to study interactions of synaptic vesicle proteins and describe a protein network of vesicle sub-populations and functional assemblies.Sabine WittigMarcelo GanzellaMarie BarthSusann KostmannDietmar RiedelÁngel Pérez-LaraReinhard JahnCarla SchmidtNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sabine Wittig
Marcelo Ganzella
Marie Barth
Susann Kostmann
Dietmar Riedel
Ángel Pérez-Lara
Reinhard Jahn
Carla Schmidt
Cross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes
description Synaptic vesicles store neurotransmitters and fuse with the pre-synaptic membrane when an action potential arrives at the nerve terminal. Here authors apply cross-linking mass spectrometry to study interactions of synaptic vesicle proteins and describe a protein network of vesicle sub-populations and functional assemblies.
format article
author Sabine Wittig
Marcelo Ganzella
Marie Barth
Susann Kostmann
Dietmar Riedel
Ángel Pérez-Lara
Reinhard Jahn
Carla Schmidt
author_facet Sabine Wittig
Marcelo Ganzella
Marie Barth
Susann Kostmann
Dietmar Riedel
Ángel Pérez-Lara
Reinhard Jahn
Carla Schmidt
author_sort Sabine Wittig
title Cross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes
title_short Cross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes
title_full Cross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes
title_fullStr Cross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes
title_full_unstemmed Cross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes
title_sort cross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c3cf31e15d2448abbfa6da7820c787aa
work_keys_str_mv AT sabinewittig crosslinkingmassspectrometryuncoversproteininteractionsandfunctionalassembliesinsynapticvesiclemembranes
AT marceloganzella crosslinkingmassspectrometryuncoversproteininteractionsandfunctionalassembliesinsynapticvesiclemembranes
AT mariebarth crosslinkingmassspectrometryuncoversproteininteractionsandfunctionalassembliesinsynapticvesiclemembranes
AT susannkostmann crosslinkingmassspectrometryuncoversproteininteractionsandfunctionalassembliesinsynapticvesiclemembranes
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AT angelperezlara crosslinkingmassspectrometryuncoversproteininteractionsandfunctionalassembliesinsynapticvesiclemembranes
AT reinhardjahn crosslinkingmassspectrometryuncoversproteininteractionsandfunctionalassembliesinsynapticvesiclemembranes
AT carlaschmidt crosslinkingmassspectrometryuncoversproteininteractionsandfunctionalassembliesinsynapticvesiclemembranes
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