Genomic investigation of a dengue virus outbreak in Thiès, Senegal, in 2018

Abstract Dengue virus is a major and rapidly growing public health concern in tropic and subtropic regions across the globe. In late 2018, Senegal experienced its largest dengue virus outbreak to date, covering several regions. However, little is known about the genetic diversity of dengue virus (DE...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Amy Gaye, Tolla Ndiaye, Mouhamad Sy, Awa B. Deme, Alphonse B. Thiaw, Aita Sene, Cheikh Ndiaye, Younouss Diedhiou, Amadou M. Mbaye, Ibrahima Ndiaye, Christopher Tomkins-Tinch, Jules F. Gomis, Aida S. Badiane, Bronwyn MacInnis, Daniel J. Park, Mouhamadou Ndiaye, Ngayo Sy, Pardis C. Sabeti, Katherine J. Siddle, Daouda Ndiaye
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c3d60b4f776f42ed8b5bc160ac7a2dd4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c3d60b4f776f42ed8b5bc160ac7a2dd4
record_format	dspace
spelling	oai:doaj.org-article:c3d60b4f776f42ed8b5bc160ac7a2dd42021-12-02T17:16:00ZGenomic investigation of a dengue virus outbreak in Thiès, Senegal, in 201810.1038/s41598-021-89070-12045-2322https://doaj.org/article/c3d60b4f776f42ed8b5bc160ac7a2dd42021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89070-1https://doaj.org/toc/2045-2322Abstract Dengue virus is a major and rapidly growing public health concern in tropic and subtropic regions across the globe. In late 2018, Senegal experienced its largest dengue virus outbreak to date, covering several regions. However, little is known about the genetic diversity of dengue virus (DENV) in Senegal. Here we report complete viral genomes from 17 previously undetected DENV cases from the city of Thiès. In total we identified 19 cases of DENV in a cohort of 198 individuals with fever collected in October and November 2018. We detected 3 co-circulating serotypes; DENV 3 was the most frequent accounting for 11/17 sequences (65%), 4 (23%) were DENV2 and 2 (12%) were DENV1. Sequences were most similar to recent sequences from West Africa, suggesting ongoing local circulation of viral populations; however, detailed inference is limited by the scarcity of available genomic data. We did not find clear associations with reported clinical signs or symptoms, highlighting the importance of testing for diagnosing febrile diseases. Overall, these findings expand the known range of DENV in Senegal, and underscore the need for better genomic characterization of DENV in West Africa.Amy GayeTolla NdiayeMouhamad SyAwa B. DemeAlphonse B. ThiawAita SeneCheikh NdiayeYounouss DiedhiouAmadou M. MbayeIbrahima NdiayeChristopher Tomkins-TinchJules F. GomisAida S. BadianeBronwyn MacInnisDaniel J. ParkMouhamadou NdiayeNgayo SyPardis C. SabetiKatherine J. SiddleDaouda NdiayeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amy Gaye Tolla Ndiaye Mouhamad Sy Awa B. Deme Alphonse B. Thiaw Aita Sene Cheikh Ndiaye Younouss Diedhiou Amadou M. Mbaye Ibrahima Ndiaye Christopher Tomkins-Tinch Jules F. Gomis Aida S. Badiane Bronwyn MacInnis Daniel J. Park Mouhamadou Ndiaye Ngayo Sy Pardis C. Sabeti Katherine J. Siddle Daouda Ndiaye Genomic investigation of a dengue virus outbreak in Thiès, Senegal, in 2018
description	Abstract Dengue virus is a major and rapidly growing public health concern in tropic and subtropic regions across the globe. In late 2018, Senegal experienced its largest dengue virus outbreak to date, covering several regions. However, little is known about the genetic diversity of dengue virus (DENV) in Senegal. Here we report complete viral genomes from 17 previously undetected DENV cases from the city of Thiès. In total we identified 19 cases of DENV in a cohort of 198 individuals with fever collected in October and November 2018. We detected 3 co-circulating serotypes; DENV 3 was the most frequent accounting for 11/17 sequences (65%), 4 (23%) were DENV2 and 2 (12%) were DENV1. Sequences were most similar to recent sequences from West Africa, suggesting ongoing local circulation of viral populations; however, detailed inference is limited by the scarcity of available genomic data. We did not find clear associations with reported clinical signs or symptoms, highlighting the importance of testing for diagnosing febrile diseases. Overall, these findings expand the known range of DENV in Senegal, and underscore the need for better genomic characterization of DENV in West Africa.
format	article
author	Amy Gaye Tolla Ndiaye Mouhamad Sy Awa B. Deme Alphonse B. Thiaw Aita Sene Cheikh Ndiaye Younouss Diedhiou Amadou M. Mbaye Ibrahima Ndiaye Christopher Tomkins-Tinch Jules F. Gomis Aida S. Badiane Bronwyn MacInnis Daniel J. Park Mouhamadou Ndiaye Ngayo Sy Pardis C. Sabeti Katherine J. Siddle Daouda Ndiaye
author_facet	Amy Gaye Tolla Ndiaye Mouhamad Sy Awa B. Deme Alphonse B. Thiaw Aita Sene Cheikh Ndiaye Younouss Diedhiou Amadou M. Mbaye Ibrahima Ndiaye Christopher Tomkins-Tinch Jules F. Gomis Aida S. Badiane Bronwyn MacInnis Daniel J. Park Mouhamadou Ndiaye Ngayo Sy Pardis C. Sabeti Katherine J. Siddle Daouda Ndiaye
author_sort	Amy Gaye
title	Genomic investigation of a dengue virus outbreak in Thiès, Senegal, in 2018
title_short	Genomic investigation of a dengue virus outbreak in Thiès, Senegal, in 2018
title_full	Genomic investigation of a dengue virus outbreak in Thiès, Senegal, in 2018
title_fullStr	Genomic investigation of a dengue virus outbreak in Thiès, Senegal, in 2018
title_full_unstemmed	Genomic investigation of a dengue virus outbreak in Thiès, Senegal, in 2018
title_sort	genomic investigation of a dengue virus outbreak in thiès, senegal, in 2018
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c3d60b4f776f42ed8b5bc160ac7a2dd4
work_keys_str_mv	AT amygaye genomicinvestigationofadenguevirusoutbreakinthiessenegalin2018 AT tollandiaye genomicinvestigationofadenguevirusoutbreakinthiessenegalin2018 AT mouhamadsy genomicinvestigationofadenguevirusoutbreakinthiessenegalin2018 AT awabdeme genomicinvestigationofadenguevirusoutbreakinthiessenegalin2018 AT alphonsebthiaw genomicinvestigationofadenguevirusoutbreakinthiessenegalin2018 AT aitasene genomicinvestigationofadenguevirusoutbreakinthiessenegalin2018 AT cheikhndiaye genomicinvestigationofadenguevirusoutbreakinthiessenegalin2018 AT younoussdiedhiou genomicinvestigationofadenguevirusoutbreakinthiessenegalin2018 AT amadoummbaye genomicinvestigationofadenguevirusoutbreakinthiessenegalin2018 AT ibrahimandiaye genomicinvestigationofadenguevirusoutbreakinthiessenegalin2018 AT christophertomkinstinch genomicinvestigationofadenguevirusoutbreakinthiessenegalin2018 AT julesfgomis genomicinvestigationofadenguevirusoutbreakinthiessenegalin2018 AT aidasbadiane genomicinvestigationofadenguevirusoutbreakinthiessenegalin2018 AT bronwynmacinnis genomicinvestigationofadenguevirusoutbreakinthiessenegalin2018 AT danieljpark genomicinvestigationofadenguevirusoutbreakinthiessenegalin2018 AT mouhamadoundiaye genomicinvestigationofadenguevirusoutbreakinthiessenegalin2018 AT ngayosy genomicinvestigationofadenguevirusoutbreakinthiessenegalin2018 AT pardiscsabeti genomicinvestigationofadenguevirusoutbreakinthiessenegalin2018 AT katherinejsiddle genomicinvestigationofadenguevirusoutbreakinthiessenegalin2018 AT daoudandiaye genomicinvestigationofadenguevirusoutbreakinthiessenegalin2018
_version_	1718381226997317632

Genomic investigation of a dengue virus outbreak in Thiès, Senegal, in 2018

Ejemplares similares