Construction and Validation of a Novel Pyroptosis-Related Gene Signature to Predict the Prognosis of Uveal Melanoma

Uveal melanoma is the most common primary intraocular tumor with a poor prognosis. Currently, treatment for UVM is limited, and the development of drug resistance and tumor recurrence are common. Therefore, it is important to identify new prognostic biomarkers of UVM and explore their role in the tu...

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Autores principales:	Yuan Cao, Jiaheng Xie, Liang Chen, Yiming Hu, Leili Zhai, Jin Yuan, Long Suo, Yaming Shen, Rong Ye, Jiajun Li, Zixuan Gong, Yunfan Dong, Wei Bao, Huan Li, Ming Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	uveal melanoma pyroptosis signature immune microenvironment programmed cell death Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c3d992369f254ff8828b3c86658d396a
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spelling	oai:doaj.org-article:c3d992369f254ff8828b3c86658d396a2021-12-01T07:43:04ZConstruction and Validation of a Novel Pyroptosis-Related Gene Signature to Predict the Prognosis of Uveal Melanoma2296-634X10.3389/fcell.2021.761350https://doaj.org/article/c3d992369f254ff8828b3c86658d396a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.761350/fullhttps://doaj.org/toc/2296-634XUveal melanoma is the most common primary intraocular tumor with a poor prognosis. Currently, treatment for UVM is limited, and the development of drug resistance and tumor recurrence are common. Therefore, it is important to identify new prognostic biomarkers of UVM and explore their role in the tumor microenvironment. Pyroptosis is a way of cell programmed death, and related research is in full throttle. However, the role of pyroptosis in UVM is unclear. In this study, we constructed the prognosis model of pyroptosis-related genes of UVM. This model can accurately guide the prognosis of UVM, and different groups differ in immune infiltration. We further verified our results in cell experiments. To some extent, our study can provide new ideas for the diagnosis and treatment of UVM.Yuan CaoJiaheng XieLiang ChenYiming HuLeili ZhaiJin YuanLong SuoYaming ShenRong YeJiajun LiZixuan GongYunfan DongWei BaoHuan LiMing WangFrontiers Media S.A.articleuveal melanomapyroptosissignatureimmune microenvironmentprogrammed cell deathBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	uveal melanoma pyroptosis signature immune microenvironment programmed cell death Biology (General) QH301-705.5
spellingShingle	uveal melanoma pyroptosis signature immune microenvironment programmed cell death Biology (General) QH301-705.5 Yuan Cao Jiaheng Xie Liang Chen Yiming Hu Leili Zhai Jin Yuan Long Suo Yaming Shen Rong Ye Jiajun Li Zixuan Gong Yunfan Dong Wei Bao Huan Li Ming Wang Construction and Validation of a Novel Pyroptosis-Related Gene Signature to Predict the Prognosis of Uveal Melanoma
description	Uveal melanoma is the most common primary intraocular tumor with a poor prognosis. Currently, treatment for UVM is limited, and the development of drug resistance and tumor recurrence are common. Therefore, it is important to identify new prognostic biomarkers of UVM and explore their role in the tumor microenvironment. Pyroptosis is a way of cell programmed death, and related research is in full throttle. However, the role of pyroptosis in UVM is unclear. In this study, we constructed the prognosis model of pyroptosis-related genes of UVM. This model can accurately guide the prognosis of UVM, and different groups differ in immune infiltration. We further verified our results in cell experiments. To some extent, our study can provide new ideas for the diagnosis and treatment of UVM.
format	article
author	Yuan Cao Jiaheng Xie Liang Chen Yiming Hu Leili Zhai Jin Yuan Long Suo Yaming Shen Rong Ye Jiajun Li Zixuan Gong Yunfan Dong Wei Bao Huan Li Ming Wang
author_facet	Yuan Cao Jiaheng Xie Liang Chen Yiming Hu Leili Zhai Jin Yuan Long Suo Yaming Shen Rong Ye Jiajun Li Zixuan Gong Yunfan Dong Wei Bao Huan Li Ming Wang
author_sort	Yuan Cao
title	Construction and Validation of a Novel Pyroptosis-Related Gene Signature to Predict the Prognosis of Uveal Melanoma
title_short	Construction and Validation of a Novel Pyroptosis-Related Gene Signature to Predict the Prognosis of Uveal Melanoma
title_full	Construction and Validation of a Novel Pyroptosis-Related Gene Signature to Predict the Prognosis of Uveal Melanoma
title_fullStr	Construction and Validation of a Novel Pyroptosis-Related Gene Signature to Predict the Prognosis of Uveal Melanoma
title_full_unstemmed	Construction and Validation of a Novel Pyroptosis-Related Gene Signature to Predict the Prognosis of Uveal Melanoma
title_sort	construction and validation of a novel pyroptosis-related gene signature to predict the prognosis of uveal melanoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c3d992369f254ff8828b3c86658d396a
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Construction and Validation of a Novel Pyroptosis-Related Gene Signature to Predict the Prognosis of Uveal Melanoma

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