Single-cell replication profiling to measure stochastic variation in mammalian replication timing

While DNA replication is temporally regulated during S-phase, variation in replication timing is not well understood. Here, the authors measure variation in replication timing using DNA copy number in single mouse ESCs and find stochastic variation to be independent of elements that regulate timing.

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Detalles Bibliográficos
Autores principales:	Vishnu Dileep, David M. Gilbert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c3d994bd2c5744a29ab1dc9159c269fd
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spelling	oai:doaj.org-article:c3d994bd2c5744a29ab1dc9159c269fd2021-12-02T15:34:17ZSingle-cell replication profiling to measure stochastic variation in mammalian replication timing10.1038/s41467-017-02800-w2041-1723https://doaj.org/article/c3d994bd2c5744a29ab1dc9159c269fd2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02800-whttps://doaj.org/toc/2041-1723While DNA replication is temporally regulated during S-phase, variation in replication timing is not well understood. Here, the authors measure variation in replication timing using DNA copy number in single mouse ESCs and find stochastic variation to be independent of elements that regulate timing.Vishnu DileepDavid M. GilbertNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vishnu Dileep David M. Gilbert Single-cell replication profiling to measure stochastic variation in mammalian replication timing
description	While DNA replication is temporally regulated during S-phase, variation in replication timing is not well understood. Here, the authors measure variation in replication timing using DNA copy number in single mouse ESCs and find stochastic variation to be independent of elements that regulate timing.
format	article
author	Vishnu Dileep David M. Gilbert
author_facet	Vishnu Dileep David M. Gilbert
author_sort	Vishnu Dileep
title	Single-cell replication profiling to measure stochastic variation in mammalian replication timing
title_short	Single-cell replication profiling to measure stochastic variation in mammalian replication timing
title_full	Single-cell replication profiling to measure stochastic variation in mammalian replication timing
title_fullStr	Single-cell replication profiling to measure stochastic variation in mammalian replication timing
title_full_unstemmed	Single-cell replication profiling to measure stochastic variation in mammalian replication timing
title_sort	single-cell replication profiling to measure stochastic variation in mammalian replication timing
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c3d994bd2c5744a29ab1dc9159c269fd
work_keys_str_mv	AT vishnudileep singlecellreplicationprofilingtomeasurestochasticvariationinmammalianreplicationtiming AT davidmgilbert singlecellreplicationprofilingtomeasurestochasticvariationinmammalianreplicationtiming
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Single-cell replication profiling to measure stochastic variation in mammalian replication timing

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