Cut-off values of serum IgG4 among three reagents, including a novel IgG4 reagent: a multicenter study

Abstract Elevated serum IgG4 is a useful marker of IgG4-related disease (IgG4-RD) activity. However, there is no uniformity in the cut-off values of IgG4 among the various reagents. The aim of this study was to compare the measured and cut-off values of IgG4 assessed using three different reagents....

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Autores principales:	Yoko Usami, Mitsutoshi Sugano, Takeshi Uehara, Masayoshi Koinuma, Nau Ishimine, Kenji Kawasaki, Kazuyoshi Yamauchi, Hideaki Hamano, Takayuki Honda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c3d99f3a5cb94f7faf69d081f1d61627
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spelling	oai:doaj.org-article:c3d99f3a5cb94f7faf69d081f1d616272021-12-02T14:25:03ZCut-off values of serum IgG4 among three reagents, including a novel IgG4 reagent: a multicenter study10.1038/s41598-021-86024-52045-2322https://doaj.org/article/c3d99f3a5cb94f7faf69d081f1d616272021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86024-5https://doaj.org/toc/2045-2322Abstract Elevated serum IgG4 is a useful marker of IgG4-related disease (IgG4-RD) activity. However, there is no uniformity in the cut-off values of IgG4 among the various reagents. The aim of this study was to compare the measured and cut-off values of IgG4 assessed using three different reagents. This study enrolled 466 IgG4-RD and non-IgG4-RD patients who required measurement of serum IgG4 levels to diagnose or treat IgG4-RD. Serum IgG4 was measured using three reagents: N-assay LA IgG4 Nittobo (Nittobo), BS-NIA IgG4 (TBS), and N Latex IgG4 (Siemens). The values obtained using the three reagents were compared, and cut-off values were calculated for each. Although there was good correlation among the results with the three reagents, the measured and cut-off values were all different. The Nittobo values were 1.4 times the TBS values and the TBS values were almost half those of the Siemens values. ROC curve analysis showed cut-off values for the Nittobo, TBS, and Siemens reagents of 1.42, 1.31, and 2.38 g/L, respectively. The measured and cut-off values of serum IgG4 vary depending on the reagents used for the assay, although there is good correlation among the values measured by the three reagents.Yoko UsamiMitsutoshi SuganoTakeshi UeharaMasayoshi KoinumaNau IshimineKenji KawasakiKazuyoshi YamauchiHideaki HamanoTakayuki HondaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoko Usami Mitsutoshi Sugano Takeshi Uehara Masayoshi Koinuma Nau Ishimine Kenji Kawasaki Kazuyoshi Yamauchi Hideaki Hamano Takayuki Honda Cut-off values of serum IgG4 among three reagents, including a novel IgG4 reagent: a multicenter study
description	Abstract Elevated serum IgG4 is a useful marker of IgG4-related disease (IgG4-RD) activity. However, there is no uniformity in the cut-off values of IgG4 among the various reagents. The aim of this study was to compare the measured and cut-off values of IgG4 assessed using three different reagents. This study enrolled 466 IgG4-RD and non-IgG4-RD patients who required measurement of serum IgG4 levels to diagnose or treat IgG4-RD. Serum IgG4 was measured using three reagents: N-assay LA IgG4 Nittobo (Nittobo), BS-NIA IgG4 (TBS), and N Latex IgG4 (Siemens). The values obtained using the three reagents were compared, and cut-off values were calculated for each. Although there was good correlation among the results with the three reagents, the measured and cut-off values were all different. The Nittobo values were 1.4 times the TBS values and the TBS values were almost half those of the Siemens values. ROC curve analysis showed cut-off values for the Nittobo, TBS, and Siemens reagents of 1.42, 1.31, and 2.38 g/L, respectively. The measured and cut-off values of serum IgG4 vary depending on the reagents used for the assay, although there is good correlation among the values measured by the three reagents.
format	article
author	Yoko Usami Mitsutoshi Sugano Takeshi Uehara Masayoshi Koinuma Nau Ishimine Kenji Kawasaki Kazuyoshi Yamauchi Hideaki Hamano Takayuki Honda
author_facet	Yoko Usami Mitsutoshi Sugano Takeshi Uehara Masayoshi Koinuma Nau Ishimine Kenji Kawasaki Kazuyoshi Yamauchi Hideaki Hamano Takayuki Honda
author_sort	Yoko Usami
title	Cut-off values of serum IgG4 among three reagents, including a novel IgG4 reagent: a multicenter study
title_short	Cut-off values of serum IgG4 among three reagents, including a novel IgG4 reagent: a multicenter study
title_full	Cut-off values of serum IgG4 among three reagents, including a novel IgG4 reagent: a multicenter study
title_fullStr	Cut-off values of serum IgG4 among three reagents, including a novel IgG4 reagent: a multicenter study
title_full_unstemmed	Cut-off values of serum IgG4 among three reagents, including a novel IgG4 reagent: a multicenter study
title_sort	cut-off values of serum igg4 among three reagents, including a novel igg4 reagent: a multicenter study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c3d99f3a5cb94f7faf69d081f1d61627
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Cut-off values of serum IgG4 among three reagents, including a novel IgG4 reagent: a multicenter study

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