Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice

Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice

Unlike males, female mice are resistant to hypothalamic inflammation and weight gain when fed a high-fat diet. Here, the authors reveal sex-specific regulation of hypothalamic microglial activation through CX3CR1 signalling, providing a potential mechanism for differential susceptibility to diet-ind...

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Detalles Bibliográficos
Autores principales: Mauricio D. Dorfman, Jordan E. Krull, John D. Douglass, Rachael Fasnacht, Fernando Lara-Lince, Thomas H. Meek, Xiaogang Shi, Vincent Damian, Hong T. Nguyen, Miles E. Matsen, Gregory J. Morton, Joshua P. Thaler
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/c3d9bcc58c004e1b9f6eb255e257f3c4
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Sumario:Unlike males, female mice are resistant to hypothalamic inflammation and weight gain when fed a high-fat diet. Here, the authors reveal sex-specific regulation of hypothalamic microglial activation through CX3CR1 signalling, providing a potential mechanism for differential susceptibility to diet-induced obesity.

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