Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice

Unlike males, female mice are resistant to hypothalamic inflammation and weight gain when fed a high-fat diet. Here, the authors reveal sex-specific regulation of hypothalamic microglial activation through CX3CR1 signalling, providing a potential mechanism for differential susceptibility to diet-ind...

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Autores principales:	Mauricio D. Dorfman, Jordan E. Krull, John D. Douglass, Rachael Fasnacht, Fernando Lara-Lince, Thomas H. Meek, Xiaogang Shi, Vincent Damian, Hong T. Nguyen, Miles E. Matsen, Gregory J. Morton, Joshua P. Thaler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c3d9bcc58c004e1b9f6eb255e257f3c4
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spelling	oai:doaj.org-article:c3d9bcc58c004e1b9f6eb255e257f3c42021-12-02T17:06:11ZSex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice10.1038/ncomms145562041-1723https://doaj.org/article/c3d9bcc58c004e1b9f6eb255e257f3c42017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14556https://doaj.org/toc/2041-1723Unlike males, female mice are resistant to hypothalamic inflammation and weight gain when fed a high-fat diet. Here, the authors reveal sex-specific regulation of hypothalamic microglial activation through CX3CR1 signalling, providing a potential mechanism for differential susceptibility to diet-induced obesity.Mauricio D. DorfmanJordan E. KrullJohn D. DouglassRachael FasnachtFernando Lara-LinceThomas H. MeekXiaogang ShiVincent DamianHong T. NguyenMiles E. MatsenGregory J. MortonJoshua P. ThalerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mauricio D. Dorfman Jordan E. Krull John D. Douglass Rachael Fasnacht Fernando Lara-Lince Thomas H. Meek Xiaogang Shi Vincent Damian Hong T. Nguyen Miles E. Matsen Gregory J. Morton Joshua P. Thaler Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice
description	Unlike males, female mice are resistant to hypothalamic inflammation and weight gain when fed a high-fat diet. Here, the authors reveal sex-specific regulation of hypothalamic microglial activation through CX3CR1 signalling, providing a potential mechanism for differential susceptibility to diet-induced obesity.
format	article
author	Mauricio D. Dorfman Jordan E. Krull John D. Douglass Rachael Fasnacht Fernando Lara-Lince Thomas H. Meek Xiaogang Shi Vincent Damian Hong T. Nguyen Miles E. Matsen Gregory J. Morton Joshua P. Thaler
author_facet	Mauricio D. Dorfman Jordan E. Krull John D. Douglass Rachael Fasnacht Fernando Lara-Lince Thomas H. Meek Xiaogang Shi Vincent Damian Hong T. Nguyen Miles E. Matsen Gregory J. Morton Joshua P. Thaler
author_sort	Mauricio D. Dorfman
title	Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice
title_short	Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice
title_full	Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice
title_fullStr	Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice
title_full_unstemmed	Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice
title_sort	sex differences in microglial cx3cr1 signalling determine obesity susceptibility in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c3d9bcc58c004e1b9f6eb255e257f3c4
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Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice

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