The impact of non-additive genetic associations on age-related complex diseases
Most genome-wide association studies assume an additive model, exclude the X chromosome, and use one reference panel. Here, the authors implement a strategy including non-additive models and find that the number of loci for age-related traits increases as compared to the additive model alone.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/c3da7a8a42bb4ca499fd3cc3c84e3a1a |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:c3da7a8a42bb4ca499fd3cc3c84e3a1a |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:c3da7a8a42bb4ca499fd3cc3c84e3a1a2021-12-02T13:39:22ZThe impact of non-additive genetic associations on age-related complex diseases10.1038/s41467-021-21952-42041-1723https://doaj.org/article/c3da7a8a42bb4ca499fd3cc3c84e3a1a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21952-4https://doaj.org/toc/2041-1723Most genome-wide association studies assume an additive model, exclude the X chromosome, and use one reference panel. Here, the authors implement a strategy including non-additive models and find that the number of loci for age-related traits increases as compared to the additive model alone.Marta Guindo-MartínezRamon AmelaSilvia Bonàs-GuarchMontserrat PuiggròsCecilia SalvoroIrene Miguel-EscaladaCaitlin E. CareyJoanne B. ColeSina RüegerElizabeth AtkinsonAaron LeongFriman SanchezCristian Ramon-CortesJorge EjarqueDuncan S. PalmerMitja KurkiFinnGen ConsortiumKrishna AragamJose C. FlorezRosa M. BadiaJosep M. MercaderDavid TorrentsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Marta Guindo-Martínez Ramon Amela Silvia Bonàs-Guarch Montserrat Puiggròs Cecilia Salvoro Irene Miguel-Escalada Caitlin E. Carey Joanne B. Cole Sina Rüeger Elizabeth Atkinson Aaron Leong Friman Sanchez Cristian Ramon-Cortes Jorge Ejarque Duncan S. Palmer Mitja Kurki FinnGen Consortium Krishna Aragam Jose C. Florez Rosa M. Badia Josep M. Mercader David Torrents The impact of non-additive genetic associations on age-related complex diseases |
| description |
Most genome-wide association studies assume an additive model, exclude the X chromosome, and use one reference panel. Here, the authors implement a strategy including non-additive models and find that the number of loci for age-related traits increases as compared to the additive model alone. |
| format |
article |
| author |
Marta Guindo-Martínez Ramon Amela Silvia Bonàs-Guarch Montserrat Puiggròs Cecilia Salvoro Irene Miguel-Escalada Caitlin E. Carey Joanne B. Cole Sina Rüeger Elizabeth Atkinson Aaron Leong Friman Sanchez Cristian Ramon-Cortes Jorge Ejarque Duncan S. Palmer Mitja Kurki FinnGen Consortium Krishna Aragam Jose C. Florez Rosa M. Badia Josep M. Mercader David Torrents |
| author_facet |
Marta Guindo-Martínez Ramon Amela Silvia Bonàs-Guarch Montserrat Puiggròs Cecilia Salvoro Irene Miguel-Escalada Caitlin E. Carey Joanne B. Cole Sina Rüeger Elizabeth Atkinson Aaron Leong Friman Sanchez Cristian Ramon-Cortes Jorge Ejarque Duncan S. Palmer Mitja Kurki FinnGen Consortium Krishna Aragam Jose C. Florez Rosa M. Badia Josep M. Mercader David Torrents |
| author_sort |
Marta Guindo-Martínez |
| title |
The impact of non-additive genetic associations on age-related complex diseases |
| title_short |
The impact of non-additive genetic associations on age-related complex diseases |
| title_full |
The impact of non-additive genetic associations on age-related complex diseases |
| title_fullStr |
The impact of non-additive genetic associations on age-related complex diseases |
| title_full_unstemmed |
The impact of non-additive genetic associations on age-related complex diseases |
| title_sort |
impact of non-additive genetic associations on age-related complex diseases |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c3da7a8a42bb4ca499fd3cc3c84e3a1a |
| work_keys_str_mv |
AT martaguindomartinez theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT ramonamela theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT silviabonasguarch theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT montserratpuiggros theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT ceciliasalvoro theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT irenemiguelescalada theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT caitlinecarey theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT joannebcole theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT sinarueger theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT elizabethatkinson theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT aaronleong theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT frimansanchez theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT cristianramoncortes theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT jorgeejarque theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT duncanspalmer theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT mitjakurki theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT finngenconsortium theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT krishnaaragam theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT josecflorez theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT rosambadia theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT josepmmercader theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT davidtorrents theimpactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT martaguindomartinez impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT ramonamela impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT silviabonasguarch impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT montserratpuiggros impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT ceciliasalvoro impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT irenemiguelescalada impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT caitlinecarey impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT joannebcole impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT sinarueger impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT elizabethatkinson impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT aaronleong impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT frimansanchez impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT cristianramoncortes impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT jorgeejarque impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT duncanspalmer impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT mitjakurki impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT finngenconsortium impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT krishnaaragam impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT josecflorez impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT rosambadia impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT josepmmercader impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases AT davidtorrents impactofnonadditivegeneticassociationsonagerelatedcomplexdiseases |
| _version_ |
1718392642334621696 |