Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires

Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires

ABSTRACT Fifty years after the discovery of Epstein-Barr virus (EBV), it remains unclear how primary infection with this virus leads to massive CD8 T-cell expansion and acute infectious mononucleosis (AIM) in young adults. AIM can vary greatly in severity, from a mild transient influenza-like illnes...

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Bibliographic Details
Main Authors: Nuray Aslan, Levi B. Watkin, Anna Gil, Rabinarayan Mishra, Fransenio G. Clark, Raymond M. Welsh, Dario Ghersi, Katherine Luzuriaga, Liisa K. Selin
Format: article
Language:EN
Published: American Society for Microbiology 2017
Subjects:
CD8
Epstein-Barr virus
TCR repertoire
cross-reactive
heterologous immunity
immune memory
Microbiology
QR1-502
Online Access:https://doaj.org/article/c3db3a6bc1614ba8b351bb1bf8e3f93e
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https://doaj.org/article/c3db3a6bc1614ba8b351bb1bf8e3f93e

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