Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers

Pentameric ligand-gated ion channels (pLGICs) are key players in neurotransmission and have been shown to be modulated by the lipid environment, however the underlying mechanism is not well understood. Here, the authors report structures of the pLGIC 5-HT3A serotonin receptor reconstituted into lipi...

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Autores principales:	Yingyi Zhang, Patricia M. Dijkman, Rongfeng Zou, Martina Zandl-Lang, Ricardo M. Sanchez, Luise Eckhardt-Strelau, Harald Köfeler, Horst Vogel, Shuguang Yuan, Mikhail Kudryashev
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c3dc1144479e42dfbcbc8d743307e558
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spelling	oai:doaj.org-article:c3dc1144479e42dfbcbc8d743307e5582021-12-02T10:52:35ZAsymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers10.1038/s41467-021-21016-72041-1723https://doaj.org/article/c3dc1144479e42dfbcbc8d743307e5582021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21016-7https://doaj.org/toc/2041-1723Pentameric ligand-gated ion channels (pLGICs) are key players in neurotransmission and have been shown to be modulated by the lipid environment, however the underlying mechanism is not well understood. Here, the authors report structures of the pLGIC 5-HT3A serotonin receptor reconstituted into lipid bilayer discs and reveal lipid–protein interactions as well as asymmetric activation of the homopentameric receptor.Yingyi ZhangPatricia M. DijkmanRongfeng ZouMartina Zandl-LangRicardo M. SanchezLuise Eckhardt-StrelauHarald KöfelerHorst VogelShuguang YuanMikhail KudryashevNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yingyi Zhang Patricia M. Dijkman Rongfeng Zou Martina Zandl-Lang Ricardo M. Sanchez Luise Eckhardt-Strelau Harald Köfeler Horst Vogel Shuguang Yuan Mikhail Kudryashev Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers
description	Pentameric ligand-gated ion channels (pLGICs) are key players in neurotransmission and have been shown to be modulated by the lipid environment, however the underlying mechanism is not well understood. Here, the authors report structures of the pLGIC 5-HT3A serotonin receptor reconstituted into lipid bilayer discs and reveal lipid–protein interactions as well as asymmetric activation of the homopentameric receptor.
format	article
author	Yingyi Zhang Patricia M. Dijkman Rongfeng Zou Martina Zandl-Lang Ricardo M. Sanchez Luise Eckhardt-Strelau Harald Köfeler Horst Vogel Shuguang Yuan Mikhail Kudryashev
author_facet	Yingyi Zhang Patricia M. Dijkman Rongfeng Zou Martina Zandl-Lang Ricardo M. Sanchez Luise Eckhardt-Strelau Harald Köfeler Horst Vogel Shuguang Yuan Mikhail Kudryashev
author_sort	Yingyi Zhang
title	Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers
title_short	Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers
title_full	Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers
title_fullStr	Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers
title_full_unstemmed	Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers
title_sort	asymmetric opening of the homopentameric 5-ht3a serotonin receptor in lipid bilayers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c3dc1144479e42dfbcbc8d743307e558
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Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers

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